Department of Neuroscience, Medical University of South Carolina, Charleston SC 29425, United States; Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston SC 29425, United States; Department of Psychology, University of New Mexico, Albuquerque, NM 87106, United States; U.S. Army Research Lab, Aberdeen Proving Ground, MD 21005, United States.
Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston SC 29425, United States.
Brain Stimul. 2018 Jul-Aug;11(4):699-708. doi: 10.1016/j.brs.2018.04.004. Epub 2018 Apr 6.
BACKGROUND: Optimal parameters of transcutaneous auricular vagus nerve stimulation (taVNS) are still undetermined. Given the vagus nerve's role in regulating heart rate (HR), it is important to determine safety and HR effects of various taVNS parameters. OBJECTIVE: We conducted two sequential trials to systematically test the effects of various taVNS parameters on HR. METHODS: 15 healthy individuals participated in the initial two-visit, crossover exploratory trial, receiving either tragus (active) or earlobe (control) stimulation each visit. Nine stimulation blocks of varying parameters (pulse width: 100 μs, 200 μs, 500 μs; frequency: 1 Hz, 10 Hz, 25 Hz) were administered each visit. HR was recorded and analyzed for stimulation-induced changes. Using similar methods and the two best parameters from trial 1 (500μs 10 Hz and 500μs 25 Hz), 20 healthy individuals then participated in a follow-up confirmatory study. RESULTS: Trial 1- There was no overall effect of the nine conditions on HR during stimulation. However multivariate analysis revealed two parameters that significantly decreased HR during active stimulation compared to control (500μs 10 Hz and 500μs 25 Hz; p < 0.01). Additionally, active taVNS significantly attenuated overall sympathetic HR rebound (post-stimulation) compared to control (p < 0.001). Trial 2-For these two conditions, active taVNS significantly decreased HR compared to control (p = 0.02), with the strongest effects at 500μs 10 Hz (p = 0.032). CONCLUSION: These studies suggest that 60s blocks of tragus stimulation are safe, and some specific parameters modulate HR. Of the nine parameters studied, 500μs 10 Hz induced the greatest HR effects.
背景：经皮耳迷走神经刺激（taVNS）的最佳参数仍未确定。鉴于迷走神经在调节心率（HR）方面的作用，确定各种 taVNS 参数的安全性和 HR 影响非常重要。
目的：我们进行了两项序贯试验，系统测试了各种 taVNS 参数对 HR 的影响。
方法：15 名健康个体参加了初始的两次就诊、交叉探索性试验，每次就诊时分别接受耳屏（主动）或耳垂（对照）刺激。每次就诊时给予 9 个不同参数的刺激块（脉冲宽度：100µs、200µs、500µs；频率：1Hz、10Hz、25Hz）。记录并分析 HR 以评估刺激引起的变化。使用类似的方法和试验 1 中的两个最佳参数（500µs 10Hz 和 500µs 25Hz），20 名健康个体随后参加了后续的验证性研究。
结果：试验 1-在刺激期间，九种条件对 HR 没有总体影响。然而，多变量分析显示，与对照相比，两种参数在主动刺激期间显著降低 HR（500µs 10Hz 和 500µs 25Hz；p<0.01）。此外，与对照相比，主动 taVNS 显著减弱了整体交感神经 HR 反弹（刺激后）（p<0.001）。试验 2-对于这两种条件，与对照相比，主动 taVNS 显著降低 HR（p=0.02），在 500µs 10Hz 时效果最强（p=0.032）。
结论：这些研究表明，60s 耳屏刺激块是安全的，并且某些特定参数可调节 HR。在研究的九种参数中，500µs 10Hz 诱导出最大的 HR 效应。
Cogn Affect Behav Neurosci. 2025-9-4
Psychophysiology. 2025-3
Front Pain Res (Lausanne). 2025-1-17
J Neural Transm (Vienna). 2015-5
Zotero 插件