Wozniak K M, Aulakh C S, Hill J L, Murphy D L
Section on Clinical Neuropharmacology, National Institute of Mental Health, Bethesda, MD 20892.
Pharmacol Biochem Behav. 1988 Jun;30(2):451-6. doi: 10.1016/0091-3057(88)90479-0.
Administration of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) to rats produced a dose-dependent hypothermia. Pretreatment with the receptor antagonist methiothepin abolished this effect, and pretreatment with haloperidol, propranolol and pindolol partially attenuated it, although methiothepin and pindolol had hyperthermic actions of their own. Other receptor antagonists including ritanserin, naloxone, clonidine, phenoxybenzamine and metergoline did not significantly modify the response elicited by subsequent 8-OH-DPAT challenge. In antidepressant studies, chronic treatment (22 days) with clorgyline attenuated the hypothermic response to 8-OH-DPAT, whereas similar duration of treatment with the tricyclics clomipramine and imipramine did not significantly modify it. Also, acute treatment for three days with each of the antidepressants did not modify 8-OH-DPAT-induced hypothermia. We conclude that rat rectal temperature can be a useful model to help assess the functional state of serotonergic mechanisms, including the adaptational changes induced by long-term antidepressant treatment.
给大鼠注射8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）会产生剂量依赖性体温过低。用受体拮抗剂甲硫哒嗪预处理可消除这种效应，用氟哌啶醇、普萘洛尔和吲哚洛尔预处理可部分减弱这种效应，尽管甲硫哒嗪和吲哚洛尔自身有升温作用。其他受体拮抗剂，包括利坦色林、纳洛酮、可乐定、酚苄明和麦角苄酯，对随后8-OH-DPAT激发引起的反应没有显著影响。在抗抑郁研究中，用氯吉兰慢性治疗（22天）可减弱对8-OH-DPAT的体温过低反应，而用三环类药物氯米帕明和丙咪嗪进行类似疗程的治疗对其没有显著影响。此外，用每种抗抑郁药进行三天的急性治疗也不会改变8-OH-DPAT诱导的体温过低。我们得出结论，大鼠直肠温度可作为一个有用的模型，有助于评估5-羟色胺能机制的功能状态，包括长期抗抑郁治疗引起的适应性变化。
