Palazidou E, Stephenson J, Butler J, Coskeran P, Chambers S, McGregor A M
Department of Psychiatry, Royal London Hospital, St Clement's, UK.
Psychopharmacology (Berl). 1995 Jun;119(3):311-4. doi: 10.1007/BF02246297.
The effects of pindolol pretreatment (2 days) on prolactin and cortisol responses to a single dose of (+)-fenfluramine (30 mg po) were examined in nine healthy male volunteers. Pindolol pretreatment attenuated the (+)-fenfluramine-induced increase in prolactin concentrations but failed to affect the (+)-fenfluramine-induced cortisol increase. These data provide evidence in support of 5-HT1A receptor involvement in the regulation of prolactin secretion but question its importance in the regulation of cortisol secretion in man.
在9名健康男性志愿者中，研究了吲哚洛尔预处理（2天）对单次口服（+）-芬氟拉明（30毫克）后催乳素和皮质醇反应的影响。吲哚洛尔预处理减弱了（+）-芬氟拉明诱导的催乳素浓度升高，但未能影响（+）-芬氟拉明诱导的皮质醇升高。这些数据为5-HT1A受体参与催乳素分泌调节提供了证据，但对其在人类皮质醇分泌调节中的重要性提出了质疑。
