前列腺癌中的内质网应激：一种具有治疗潜力的脆弱性？
ER stress in prostate cancer: A therapeutically exploitable vulnerability?
机构信息
Department of Genitourinary Medical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA.
出版信息
Sci Transl Med. 2018 May 2;10(439). doi: 10.1126/scitranslmed.aat3975.
PMID:29720450
Abstract
Cooperative oncogenic effects resulting from the loss of PTEN and overexpression of MYC overcome the deleterious effects of endoplasmic reticulum stress not only to promote the growth of aggressive prostate cancer but also to expose a new therapy target for this disease (Nguyen , this issue).
摘要
PTEN 缺失和 MYC 过表达导致的协同致癌效应不仅克服了内质网应激的有害影响，促进了侵袭性前列腺癌的生长，而且为这种疾病提供了一个新的治疗靶点（Nguyen，本期）。
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