使用还原氧化石墨烯-氮化钛纳米复合材料电化学检测 NGF。
Electrochemical detection of NGF using a reduced graphene oxide- titanium nitride nanocomposite.
机构信息
Department of Oncology, Henan Academy Institute of Traditional Chinese Medicine, Zhengzhou, 450004, Henan, China.
Department of Traditional Chinese Medicine, Henan Province People Hospital, Zhengzhou, 450004, Henan, China.
出版信息
Sci Rep. 2018 May 2;8(1):6929. doi: 10.1038/s41598-018-25196-z.
There is a correlation between the severity of neurological impairment in patients that have suffered a cerebrovascular accident and the nerve growth factor (NGF) level. This study addressed the fabrication of a titanium nitride (TiN) and reduced graphene oxide (RGO)-based composite with remarkable electrocatalytic activity towards NGF oxidation in a phosphate buffer solution (PB, 0.1 M). The proposed electrochemical sensor was linearly related to the NGF concentration in the range of 10 nM-5 μM with a detection limit of 2.6 nM.
在患有脑血管意外的患者中，神经损伤的严重程度与神经生长因子（NGF）水平之间存在相关性。本研究制备了一种氮化钛（TiN）和还原氧化石墨烯（RGO）基复合材料，在磷酸盐缓冲溶液（PB，0.1 M）中对 NGF 氧化具有显著的电催化活性。所提出的电化学传感器与 NGF 浓度在 10 nM-5 μM 的范围内呈线性关系，检测限为 2.6 nM。
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