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关于伴有孤立性脑转移的Her2阳性乳腺癌的实用共识建议。

Practical consensus recommendations on Her2 +ve breast cancer with solitary brain mets.

作者信息

Rohatgi Nitesh, Munshi A, Bajpai P, Singh M, Sahai S, Ahmad M, Singh K, Singh H, Parikh Purvish M, Aggarwal S

机构信息

Department of Medical Oncology, Max Hospital, New Delhi, India.

Department of Radiation Oncology, Fortis Hospital, Gurugram, Haryana, India.

出版信息

South Asian J Cancer. 2018 Apr-Jun;7(2):118-122. doi: 10.4103/sajc.sajc_116_18.

Abstract

Breast cancer is a common cause of brain metastases, with metastases occurring in at least 10-16% of patients. Longer survival of patients with metastatic breast cancer and the use of better imaging techniques are associated with an increased incidence of brain metastases. Current therapies include surgery, whole-brain radiation therapy, stereotactic radiosurgery, chemotherapy and targeted therapies. However, the timing and appropriate use of these therapies is controversial and careful patient selection by using available prognostic tools is extremely important. Expert oncologist discussed on the mode of treatment to extend the OS and improve the quality of life ofHER2-positivebreast cancer patients with Solitary brain metastases. This expert group used data from published literature, practical experience and opinion of a large group of academic oncologists to arrive at this practical consensus recommendations for the benefit of community oncologists.

摘要

乳腺癌是脑转移的常见原因,至少10%-16%的患者会发生转移。转移性乳腺癌患者生存期延长以及更好的成像技术的应用与脑转移发生率增加相关。目前的治疗方法包括手术、全脑放射治疗、立体定向放射外科、化疗和靶向治疗。然而,这些治疗的时机和适当应用存在争议,通过使用可用的预后工具仔细选择患者极为重要。专家肿瘤学家讨论了延长HER2阳性孤立性脑转移乳腺癌患者总生存期(OS)并改善其生活质量的治疗模式。该专家组利用已发表文献的数据、实践经验以及一大批学术肿瘤学家的意见,得出了这些实用的共识性建议,以造福社区肿瘤学家。

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