Shadmi A L, Lunenfeld B, Bahari C, Kokia E, Pariente C, Blankstein J
Department of Obstetrics, Gynecology and Endocrinology, Chaim Sheba Medical Center, Sackler Medical School, Tel-Aviv University, Tel-Hashomer, Israel.
Gynecol Endocrinol. 1987 Mar;1(1):1-11. doi: 10.3109/09513598709082691.
The hypothalamic pituitary axis was studied in patients with an abnormal pattern of gonadotropin release during chronic treatment with LH-RH agonist. Two patients had PCOD and the third demonstrated the early luteinization phenomenon. Following a well-defined gonadotropin rise with initiation of LH-RH treatment, no further response was noted. Stabilization of the LH:FSH ratio in PCOD patients was noted after 4 weeks of treatment. Administration of both native LH-RH (100 micrograms) and intravenous pulsatile LH-RH did not evoke any rise in LH. In addition to the above LH-RH challenges, the positive feedback was examined by administration of estradiol benzoate (EB). The study demonstrated that, although the pituitary did not respond to any LH-RH challenge, it may still respond by a rise in LH following EB administration. Both functions of the hypothalamic pituitary axis should be examined in order to determine the state of medical hypophysectomy.
在接受促黄体生成素释放激素（LH-RH）激动剂长期治疗期间，对促性腺激素释放模式异常的患者的下丘脑 - 垂体轴进行了研究。两名患者患有多囊卵巢综合征（PCOD），第三名患者表现出早期黄体化现象。在开始LH-RH治疗后促性腺激素有明确升高，但未观察到进一步反应。治疗4周后，PCOD患者的LH:FSH比值稳定。给予天然LH-RH（100微克）和静脉脉冲式LH-RH均未引起LH升高。除上述LH-RH激发试验外，还通过给予苯甲酸雌二醇（EB）来检测正反馈。研究表明，尽管垂体对任何LH-RH激发试验均无反应，但在给予EB后仍可能通过LH升高做出反应。为了确定药物性垂体切除的状态，应检查下丘脑 - 垂体轴的这两种功能。
