Barrera-Mendoza Columba Citlalli, Ayala-Mata Francisco, Cortés-Rojo Christian, García-Pérez Martha Estrella, Rodríguez-Orozco Alain Raimundo
Instituto de Investigaciones Científicas en Temas de Familia, Alergia e Inmunología, Morelia, Michoacán, México.
Rev Alerg Mex. 2018 Jan-Mar;65(1):61-77. doi: 10.29262/ram.v65i1.306.
Asthma is a condition of unknown etiology characterized by chronic airway inflammation. Cells that mediate the inflammatory response generate reactive oxygen species that, together with other respiratory tract naturally-occurring oxidant species, produce a rupture of the redox balance, generating oxidative stress. It has been proposed that oxidative stress can be reverted by supplemental or dietary intake of antioxidant vitamins such as vitamin A, C, D and E, and this way relieve, improve or protect people with asthma. In this research, observational and placebo-controlled trials with regard to the role of antioxidant vitamins in the course of asthma, published between 1979 and 2016, were reviewed. The search engines were Google and Google Scholar, whereas consulted databases were PubMed and The Cochrane Library. There were 75 articles relevant to the subject that were found and reviewed, and it was concluded that it is not clear if the intake of supplements of these vitamins has any beneficial clinical effect on asthma control. Further controlled, longer trials are needed to elucidate the role of these nutrients in the course of asthma.
哮喘是一种病因不明的疾病，其特征为慢性气道炎症。介导炎症反应的细胞会产生活性氧物质，这些物质与呼吸道中其他天然存在的氧化物质一起，导致氧化还原平衡被打破，从而产生氧化应激。有人提出，通过补充或从饮食中摄入抗氧化维生素（如维生素A、C、D和E）可以逆转氧化应激，进而缓解、改善哮喘患者的状况或对其起到保护作用。在本研究中，我们回顾了1979年至2016年间发表的关于抗氧化维生素在哮喘病程中作用的观察性和安慰剂对照试验。搜索引擎为谷歌和谷歌学术，查阅的数据库为PubMed和考克兰图书馆。共找到并回顾了75篇与该主题相关的文章，得出的结论是，目前尚不清楚摄入这些维生素补充剂对哮喘控制是否具有任何有益的临床效果。需要进一步开展对照的、更长时间的试验，以阐明这些营养素在哮喘病程中的作用。
