Li Cun-Yu, Wu Xin, Gu Jia-Mei, Li Hong-Yang, Peng Guo-Ping
College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing 210023, China.
Zhongguo Zhong Yao Za Zhi. 2018 Apr;43(7):1453-1458. doi: 10.19540/j.cnki.cjcmm.20180117.007.
Based on the molecular sieving and solution-diffusion effect in nanofiltration separation, the correlation between initial concentration and mass transfer coefficient of three typical phenolic acids from Salvia miltiorrhiza was fitted to analyze the relationship among mass transfer coefficient, molecular weight and concentration. The experiment showed a linear relationship between operation pressure and membrane flux. Meanwhile, the membrane flux was gradually decayed with the increase of solute concentration. On the basis of the molecular sieving and solution-diffusion effect, the mass transfer coefficient and initial concentration of three phenolic acids showed a power function relationship, and the regression coefficients were all greater than 0.9. The mass transfer coefficient and molecular weight of three phenolic acids were negatively correlated with each other, and the order from high to low is protocatechualdehyde >rosmarinic acid> salvianolic acid B. The separation mechanism of nanofiltration for phenolic acids was further clarified through the analysis of the correlation of molecular weight and nanofiltration mass transfer coefficient. The findings provide references for nanofiltration separation, especially for traditional Chinese medicine with phenolic acids.
基于纳滤分离中的分子筛效应和溶解-扩散效应，对丹参中三种典型酚酸的初始浓度与传质系数之间的相关性进行拟合，以分析传质系数、分子量和浓度之间的关系。实验表明操作压力与膜通量呈线性关系。同时，膜通量随溶质浓度的增加而逐渐衰减。基于分子筛效应和溶解-扩散效应，三种酚酸的传质系数与初始浓度呈幂函数关系，回归系数均大于0.9。三种酚酸的传质系数与分子量呈负相关，由高到低依次为原儿茶醛＞迷迭香酸＞丹酚酸B。通过分析分子量与纳滤传质系数的相关性，进一步阐明了纳滤对酚酸的分离机制。研究结果为纳滤分离，尤其是含酚酸的中药纳滤分离提供了参考。
