Arnaud-Franco Gustavo, Cordero-Tapia Amaury, Ortíz-Ávila Víctor, Moctezuma-González Claudia Lizbeth, Tejocote-Pérez Moisés, Carbajal-Saucedo Alejandro
Centro de Investigaciones Biológicas del Noroeste SC, Instituto Politécnico Nacional, #195 Col. Playa Palo Santa Rita, La Paz, BCS, CP 23096, Mexico.
Centro de Investigación en Ciencias Biológicas Aplicadas, Universidad Autónoma del Estado de México, Carretera Toluca Ixtlahuaca Km 14.5, San Cayetano Morelos, Toluca, CP 50200, Mexico.
Toxicon. 2018 Jun 15;148:197-201. doi: 10.1016/j.toxicon.2018.04.030. Epub 2018 May 4.
In Mexico more than 40% of reported snakebites are due to rattlesnake species. In general, the venoms of these snakes are characterized by the presence of highly enzymatic components that could provoke coagulopathies, local and systemic tissue damage and some cases neurotoxicity. In northwestern Mexico (Baja California Peninsula, Gulf of California and Pacific islands), 15 species of Crotalus are distributed. Such a biodiversity implies a high variability in venom compositions that in turns would results in high variability in clinical manifestations. In this work, venoms of Crotalus catalinensis, C. enyo enyo, C. mitchellii mitchellii and C. ruber lucasensis were studied. Lethal doses from 0.35 to 9.21 mg/kg were obtained being venom of C. m. mitchellii the most potent of all. Venoms of C. catalinensis, C. e. enyo and C. r. lucasensis show high hemorrhagic potency (1.34, 1.48 and 1.68 μg respectively). Coagulant activity was found in venoms of C. catalinensis (4.6 μg), C. e. enyo (101.9 μg) and C. m. mitchellii (13.6 μg). Our results point out hemorrhage as one of the most expected signs by three of the four most abundant species in the area. Also, neurotoxicity must be expected by C. m. mitchellii.
