栀子红根及茎皮中的三萜皂苷：红根苷 A-J。
Erythrosaponins A-J, triterpene saponins from the roots and stem bark of Gardenia erythroclada.
机构信息
Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Natural Products Research Section, Research Division, National Cancer Institute, Bangkok, 10400, Thailand.
出版信息
Phytochemistry. 2018 Aug;152:36-44. doi: 10.1016/j.phytochem.2018.04.016. Epub 2018 May 3.
Ten undescribed triterpene saponins, named erythrosaponins A-J, along with one known analogue were isolated from the roots and stem bark of Gardenia erythroclada. Their structures were determined on the basis of extensive 1D and 2D NMR analyses. Absolute structure of erythrosaponin A was unequivocally affirmed by single-crystal X-ray crystallography. All isolated compounds were evaluated for their cytotoxicity against cancer cell lines (KB and HeLa S-3) and their anti-inflammatory activity based on the inhibition of NO production in RAW264.7 cells. Erythrosaponin D showed moderate cytotoxicity against KB and HeLa S-3 cells with IC values of 25.8 and 29.5 μM, respectively. Erythrosaponins D, F, G, I and J showed moderate anti-inflammatory with IC values in the range of 63.0-81.4 μM.
从栀子红根和茎皮中分离得到了 10 种未描述的三萜皂苷，命名为 erythrosaponins A-J，以及一种已知类似物。根据广泛的 1D 和 2D NMR 分析确定了它们的结构。通过单晶 X 射线晶体学明确确定了 erythrosaponin A 的绝对结构。所有分离得到的化合物都进行了细胞毒性测试，评估了它们对癌细胞系（KB 和 HeLa S-3）的抑制作用，并基于 RAW264.7 细胞中 NO 产生的抑制作用评估了它们的抗炎活性。Erythrosaponin D 对 KB 和 HeLa S-3 细胞表现出中等的细胞毒性，IC 值分别为 25.8 和 29.5 μM。Erythrosaponins D、F、G、I 和 J 具有中等的抗炎活性，IC 值范围为 63.0-81.4 μM。
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