School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Molecules. 2023 Mar 24;28(7):2928. doi: 10.3390/molecules28072928.
Panax ginseng (), the dried root and rhizome of C. A. Meyer, is widely used in many fields as dietary supplements and medicine. To characterize the chemical constituents in cultivated in different growth environments, a UPLC-TOF-MS method was established for qualitative analysis. Four hundred and eight ginsenosides, including 81 new compounds, were characterized in from different regions. Among the detected compounds, 361 ginsenosides were recognized in cultivated in the region of Monsoon Climate of Medium Latitudes, possessing the largest amount of ginsenosides in all samples. Furthermore, 41 ginsenosides in 12 batches of were quantified with a UPLC-MRM-MS method, and from different regions were distinguished via chemometric analysis. This study showed that the different environments have a greater influence on , which laid a foundation for further quality control of the herb.
人参（Panax ginseng），即五加科植物人参的干燥根及根茎，被广泛应用于膳食补充剂和医药等诸多领域。为了鉴定不同生长环境下人工种植的人参中的化学成分，本研究建立了一种基于 UPLC-TOF-MS 的定性分析方法。共鉴定出 408 种人参皂苷，包括 81 种新化合物，这些化合物均来自不同产地的人工种植人参。在所检测的化合物中，41 种人参皂苷在具有季风性中纬度气候的地区的人工种植人参中含量最高，占所有样品中人参皂苷总量的比例最大。此外，采用 UPLC-MRM-MS 法对 12 批不同产地的人参中的 41 种人参皂苷进行了定量分析，并通过化学计量学分析对不同产地的人参进行了区分。本研究表明，不同环境对人参的影响更大，为该草药的进一步质量控制奠定了基础。
