前列腺素E2和心房肽III对大鼠肾系膜细胞培养物中血管紧张素II的收缩作用起拮抗作用。
Prostaglandin E2 and atriopeptin III oppose the contractile effect of angiotensin II in rat kidney mesangial cell cultures.
作者信息
Fandrey J, Jelkmann W
机构信息
Institut für Physiologie, Medizinische Universität zu Lübeck, FRG.
出版信息
Prostaglandins. 1988 Aug;36(2):249-57. doi: 10.1016/0090-6980(88)90311-5.
Effects of vasoconstrictory and of dilatory hormones were studied on the contractile activity of cultured rat kidney mesangial cells. By phase contrast microscopy, a rapid contraction was seen of most cells treated with angiotensin II (10(-6) - 10(-10) mol/L), which was sometimes followed by autonomous relaxation after 10 to 20 min. Prostaglandin E2 and atriopeptin III prevented the contractile effect of angiotensin II in a dose-dependent manner. Angiotensin II, but not atriopeptin III, stimulated prostaglandin E2 synthesis in mesangial cell cultures.
研究了血管收缩激素和舒张激素对培养的大鼠肾系膜细胞收缩活性的影响。通过相差显微镜观察到，大多数用血管紧张素II（10^(-6)-10^(-10)mol/L）处理的细胞会迅速收缩，有时在10至20分钟后会自主松弛。前列腺素E2和心房肽III以剂量依赖的方式阻止了血管紧张素II的收缩作用。血管紧张素II而非心房肽III刺激了系膜细胞培养物中前列腺素E2的合成。
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