日本肾移植受者中PCK2基因多态性与新发葡萄糖不耐受的关联
Association of the PCK2 Gene Polymorphism With New-onset Glucose Intolerance in Japanese Kidney Transplant Recipients.
作者信息
Yokoyama N, Ishimura T, Oda T, Ogawa S, Yamamoto K, Fujisawa M
机构信息
Division of Urology, Department of Surgery Related, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Division of Urology, Department of Surgery Related, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
出版信息
Transplant Proc. 2018 May;50(4):1045-1049. doi: 10.1016/j.transproceed.2018.01.042.
BACKGROUND
New-onset diabetes mellitus after transplantation (NODAT) is a risk factor for both cardiovascular disease and poor graft survival after kidney transplantation (KTx). In this study, we identified single-nucleotide polymorphisms (SNPs) in genes involved in glucose metabolism and examined the correlation between these SNPs and glucose intolerance after KTx.
METHODS
Thirty-eight patients with normal glucose tolerance before KTx were included in this study. Patients with plasma glucose levels of >140 mg/dL at 120 minutes on the 75-g oral glucose tolerance test at 1 year after KTx were classified as having new-onset impaired glucose tolerance (NIGT). We identified 8 SNPs in 7 genes that are involved in glucose metabolism among the patients included in this study, and compared the prevalence rate of NIGT among SNPs in each gene.
RESULTS
Of the 38 patients, 11 (28.9%) were diagnosed with NIGT. For rs4982856 in the PCK2 gene, the distribution of genotypes among the total patient population was as follows: T/T, 12 (31.6%); T/C, 22 (57.9%); and C/C, 4 (10.5%). Seven of 11 patients with NIGT had the T/T genotype of rs4982856, whereas only 5 of 27 patients with normal glucose tolerance had this genotype. The T allele frequency of the rs4982856 was significantly higher in the NIGT group than in the normal group (81.8 vs 52.8%, respectively; P = .015).
CONCLUSION
Our study indicates that the T allele of the rs4982856 SNP in the PCK2 gene may be a risk factor for glucose intolerance after KTx.
背景
移植后新发糖尿病（NODAT）是肾移植（KTx）后心血管疾病和移植肾存活率低的危险因素。在本研究中，我们鉴定了参与葡萄糖代谢的基因中的单核苷酸多态性（SNP），并研究了这些SNP与KTx后葡萄糖不耐受之间的相关性。
方法
本研究纳入了38例KTx前糖耐量正常的患者。KTx后1年，在75g口服葡萄糖耐量试验中120分钟时血浆葡萄糖水平>140mg/dL的患者被分类为新发糖耐量受损（NIGT）。我们在本研究纳入的患者中鉴定了7个参与葡萄糖代谢的基因中的8个SNP，并比较了每个基因中SNP的NIGT患病率。
结果
38例患者中，11例（28.9%）被诊断为NIGT。对于PCK2基因中的rs4982856，总患者群体中的基因型分布如下：T/T，12例（31.6%）；T/C，22例（57.9%）；C/C，4例（10.5%）。11例NIGT患者中有7例具有rs4982856的T/T基因型，而27例糖耐量正常的患者中只有5例具有该基因型。rs4982856的T等位基因频率在NIGT组中显著高于正常组（分别为81.8%和52.8%；P = 0.015）。
结论
我们的研究表明，PCK2基因中rs4982856 SNP的T等位基因可能是KTx后葡萄糖不耐受的危险因素。
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