Kadohisa M, Sugawara Y, Shimata K, Kawabata S, Narita Y, Uto K, Yoshii D, Hayashida S, Oya Y, Yamamoto H, Yamamoto H, Inomata Y, Hibi T
Department of Transplantation and Pediatric Surgery, Kumamoto University, Kumamoto, Japan.
Department of Transplantation and Pediatric Surgery, Kumamoto University, Kumamoto, Japan.
Transplant Proc. 2018 May;50(4):1129-1131. doi: 10.1016/j.transproceed.2018.01.026.
Donor safety is one of the most important factors in living-donor liver transplantation. Duodenal ulcer (DU) is a common postoperative complication. Here we aimed to reveal the risk factors associated with postoperative DU in the donors.
Between April 2007 and March 2017, 318 cases underwent donor hepatectomy for liver transplantation at Kumamoto University Hospital. We classified the donors into two groups: a DU group and a non-DU group. DU was defined as mucosal break with unequivocal depth requiring an endoscopic procedure. The characteristics and clinical factors of the donors were retrospectively analyzed.
Postoperative DU occurred in 17 donors during the study period. The mean interval after donor hepatectomy to occurrence of DU was 124.8 ± 185.4 days. The two groups were comparable in terms of age at time of the donor hepatectomy (P = .45). The male-to-female ratio (P = .03) was significantly different between the two groups and left-side hepatectomy was performed more often in the DU group (P = .003). Multivariable logistic regression revealed that left-side hepatectomy was independently associated with postoperative DU in the donors.
These findings indicated that left-side hepatectomy is a risk factor for postoperative DU in the donors.
供体安全是活体肝移植中最重要的因素之一。十二指肠溃疡（DU）是一种常见的术后并发症。在此，我们旨在揭示供体术后发生DU的相关危险因素。
2007年4月至2017年3月期间，熊本大学医院有318例患者接受了供体肝切除术以进行肝移植。我们将供体分为两组：DU组和非DU组。DU定义为需要内镜检查明确深度的黏膜破损。对供体的特征和临床因素进行回顾性分析。
在研究期间，17例供体发生了术后DU。供体肝切除术后至DU发生的平均间隔时间为124.8±185.4天。两组在供体肝切除术时的年龄方面具有可比性（P = 0.45）。两组的男女比例（P = 0.03）存在显著差异，且DU组更常进行左侧肝切除术（P = 0.003）。多变量逻辑回归显示，左侧肝切除术与供体术后DU独立相关。
这些发现表明，左侧肝切除术是供体术后发生DU的一个危险因素。
