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近期新生儿脑的临床前和临床多模态磁共振研究进展。

Recent advances in preclinical and clinical multimodal MR in the newborn brain.

机构信息

Department of Pediatrics, University of Montréal, Research Center, CHU Sainte-Justine, Montréal, Québec, Canada.

Department of Pediatrics, University of Montréal, Research Center, CHU Sainte-Justine, Montréal, Québec, Canada; Department of Pharmacology and Physiology, Université de Montréal, Montréal, Québec, Canada.

出版信息

J Magn Reson. 2018 Jul;292:149-154. doi: 10.1016/j.jmr.2018.04.017. Epub 2018 Apr 30.

Abstract

Aside from injury identification, MRI of the newborn brain has given us insight into cortical and white matter development, identified windows of vulnerabilities, enabled the introduction of therapeutic hypothermia which has become the standard of care in neonatal asphyxia, and is fostering leapfrogging discoveries in the field of neuro-genetics. This article reviews the main advances in recent years in newborn brain imaging both in preclinical and clinical research.

摘要

除了损伤识别,新生儿脑 MRI 使我们深入了解了皮质和白质发育,确定了易损窗口,使得治疗性低体温得以引入并成为新生儿窒息治疗的标准,并且正在推动神经遗传学领域的跨越式发现。本文综述了近年来在临床前和临床研究中新生儿脑成像的主要进展。

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