Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA; These authors contributed equally.
Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA; MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA.
Trends Mol Med. 2018 Jun;24(6):524-526. doi: 10.1016/j.molmed.2018.04.006. Epub 2018 May 3.
In a recent study, Kooreman and colleagues identify a set of genes expressed in both induced pluripotent stem cells (iPSCs) and cancer cells. Vaccination of mice with iPSCs induces prophylactic and therapeutic anticancer immunity to shared antigens, opening a possible avenue towards rapid generation of iPSC-based, personalized cancer vaccines.
在最近的一项研究中，Kooreman 及其同事鉴定了一组在诱导多能干细胞（iPSC）和癌细胞中都表达的基因。用 iPSC 对小鼠进行疫苗接种会诱导针对共同抗原的预防性和治疗性抗癌免疫，为快速生成基于 iPSC 的个性化癌症疫苗开辟了一条可能的途径。
