Sangle Varsha A, Chaware Smita J, Kulkarni Meena A, Ingle Yashwant C, Singh Pratibha, Pooja V K
Department of Oral Pathology and Microbiology, MIDSR Dental College, Ambajogai Road, Latur, Maharashtra, India.
Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Pimpri, Maharashtra, India.
J Oral Maxillofac Pathol. 2018 Jan-Apr;22(1):35-39. doi: 10.4103/jomfp.JOMFP_27_16.
Nitric oxide (NO) is a diatomic molecule that has been implicated in tumor progression of oral squamous cell carcinoma (OSCC). However, the mechanism of NO affecting tumor growth and progression remains unknown. Tumor progression has been recently received considerable attention, and there is increasing evidence of correlation of tumor biology and behavior.
We aim to evaluate tissue NO of OSCC patients and correlate these findings with grade and stage of the OSCC patients.
To count tissue nitric oxide in normal and OSCC cases. To compare the findings of tissue nitric oxide between normal and OSCC cases.
Forty-two fresh tissue specimens from the excisional biopsy of OSCC patients and 42 tissue samples of normal healthy mucosa using ultraviolet visible spectrophotometer.
Statistical analysis was done using Student's unpaired -test and Tukey's analysis.
Tissue NO level was higher in OSCC compared with control group ( < 0.01). There was an increase in NO levels with advanced clinical staging and with decreased differentiation of tumor.
Increased tissue NO levels in OSCC patients along with an increase in the clinical stage of the tumor and decreased differentiation of tumor indicates the association of NO with tumor growth and with staging and grading of is well recognized.
一氧化氮（NO）是一种双原子分子，与口腔鳞状细胞癌（OSCC）的肿瘤进展有关。然而，NO影响肿瘤生长和进展的机制尚不清楚。肿瘤进展最近受到了相当多的关注，并且越来越多的证据表明肿瘤生物学与行为之间存在相关性。
我们旨在评估OSCC患者的组织NO，并将这些发现与OSCC患者的分级和分期相关联。
对正常和OSCC病例的组织一氧化氮进行计数。比较正常和OSCC病例之间组织一氧化氮的检测结果。
使用紫外可见分光光度计对42例OSCC患者切除活检的新鲜组织标本和42例正常健康黏膜组织样本进行检测。
采用学生氏非配对t检验和Tukey分析进行统计分析。
与对照组相比，OSCC患者的组织NO水平更高（P<0.01）。随着临床分期的进展和肿瘤分化程度的降低，NO水平升高。
OSCC患者组织NO水平升高，同时肿瘤临床分期增加和肿瘤分化降低，这表明NO与肿瘤生长以及分期和分级之间的关联已得到充分认识。
