Aziz Niloufa Z, Arathi K, Prasad B Ganesh, Desai Dinkar, Shetty Sharan J, Shahid Mohammed
Department of Oral Pathology, A. J. Institute of Dental Sciences, Mangalore, Karnataka, India.
J Oral Maxillofac Pathol. 2018 Jan-Apr;22(1):147. doi: 10.4103/jomfp.JOMFP_34_17.
Cancer is Latinized from Greek word 'karkinos' meaning crab, denoting how carcinoma extends its claws like a crab into adjacent tissues. It has been well established by researchers that virtually all oral cancer are preceded by visible clinical changes in the oral mucosa usually in the form of white or red patch (two-step process of cancer development). Mg is an essential mineral that is needed for a broad variety of physiological functions. Imbalances in Mg metabolism are common and are associated with different pathological conditions. The purpose of this study was to evaluate and compare the magnesium concentration in blood serum and saliva of oral squamous cell carcinoma, potentially malignant disorders and healthy subjects to serve as a positive marker or indicator in the process of carcinogenesis.
The study includes 17 precancerous (OSMF + Leukoplakia) patients, 17 OSCC and 17 control group. Blood and saliva was collected; serum and saliva was extracted from both the groups and was biochemically evaluated for magnesium levels. Statistical analysis was performed using ANOVA.
The Salivary magnesium Mean ± SD of Healthy group is higher 1.6681 ± 0.0207 mmol mg/l followed by Potentially Malignant Disorder group 1.5532 ± 0.0283 and Oral Squamous Cell Carcinoma 0.5979 ± 0.0659. The mean values differ significantly between 3 groups ( < 0.001) The Serum magnesium Mean ± SD of Healthy group is higher 1.9188 ± 0.0550 mmol mg/l followed by Potentially Malignant Disorder group 1.6951 ± 0.0949 and Oral Squamous Cell Carcinoma 0.7329 ± 0.1561. The mean values differ significantly between 3 groups ( < 0.001) The study revealed decreased serum and salivary magnesium in oral precancerous patients and an Oral Squamous cell carcinoma patients compared to healthy individuals.
The magnesium concentration was low in both blood plasma and saliva of oral squamous cell carcinoma as compared to potentially malignant disorders and healthy subjects. Thus the magnesium ion concentration in blood plasma and saliva could be considerd as tumor marker, playing an important role in carcinogenesis.
癌症一词源于希腊语“karkinos”的拉丁化形式，意为螃蟹，用以表示癌如何像螃蟹一样将其爪子延伸至邻近组织。研究人员已充分证实，几乎所有口腔癌之前口腔黏膜都会出现可见的临床变化，通常表现为白色或红色斑块（癌症发展的两步过程）。镁是一种必需矿物质，多种生理功能都需要它。镁代谢失衡很常见，且与不同的病理状况相关。本研究的目的是评估和比较口腔鳞状细胞癌、潜在恶性疾病患者及健康受试者血清和唾液中的镁浓度，以作为致癌过程中的阳性标志物或指标。
该研究纳入17名癌前病变（口腔黏膜下纤维化+白斑）患者、17名口腔鳞状细胞癌患者和17名对照组。采集血液和唾液；从两组中提取血清和唾液，并对镁水平进行生化评估。采用方差分析进行统计分析。
健康组唾液镁均值±标准差较高，为1.6681±0.0207mmol mg/l，其次是潜在恶性疾病组1.5532±0.0283，口腔鳞状细胞癌组为0.5979±0.0659。三组间均值差异显著（<0.001）。健康组血清镁均值±标准差较高，为1.9188±0.0550mmol mg/l，其次是潜在恶性疾病组1.6951±0.0949，口腔鳞状细胞癌组为0.7329±0.1561。三组间均值差异显著（<0.001）。研究显示，与健康个体相比，口腔癌前病变患者和口腔鳞状细胞癌患者的血清和唾液镁含量降低。
与潜在恶性疾病患者和健康受试者相比，口腔鳞状细胞癌患者血浆和唾液中的镁浓度较低。因此，血浆和唾液中的镁离子浓度可被视为肿瘤标志物，在致癌过程中发挥重要作用。
