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慢性阻塞性肺疾病的严重程度及其与阻塞性睡眠呼吸暂停综合征的关联：对心脏自主神经调节和功能能力的影响。

Chronic obstructive pulmonary disease severity and its association with obstructive sleep apnea syndrome: impact on cardiac autonomic modulation and functional capacity.

作者信息

Zangrando Katiany Thays Lopes, Trimer Renata, de Carvalho Luiz Carlos Soares, Arêas Guilherme Peixoto Tinoco, Caruso Flávia Cristina Rossi, Cabiddu Ramona, Roscani Meliza Goi, Rizzatti Fabíola Paula Galhardo, Borghi-Silva Audrey

机构信息

Cardiopulmonary Physiotherapy Laboratory, Physiotherapy Department, Federal University of São Carlos, São Carlos, São Paulo, Brazil.

Physical Education and Health Department, University of Santa Cruz do Sul, Santa Cruz do Sul, Rio Grande do Sul, Brazil.

出版信息

Int J Chron Obstruct Pulmon Dis. 2018 Apr 26;13:1343-1351. doi: 10.2147/COPD.S156168. eCollection 2018.

DOI:10.2147/COPD.S156168
PMID:29731622
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5927062/
Abstract

BACKGROUND: The study was conducted to determine the impact of chronic obstructive pulmonary disease (COPD) in association with obstructive sleep apnea syndrome (OSAS) on cardiac autonomic control and functional capacity. SUBJECTS AND METHODS: The study was a cross-sectional prospective controlled clinical study. Heart rate variability indices of 24 COPD (n = 12) and COPD+OSAS (n = 12) patients were evaluated and compared by electrocardiographic recordings acquired during rest, active postural maneuver (APM), respiratory sinus arrhythmia maneuver (RSA-m), and the 6-minute walk test (6MWT). RESULTS: The COPD group presented higher parasympathetic modulation during APM when compared to the COPD+OSAS group ( = 0.02). The COPD+OSAS group presented higher sympathetic modulation during RSA-m when compared to the COPD group ( = 0.00). The performance during 6MWT was similarly impaired in both groups, despite the greater severity of the COPD group. CONCLUSION: Subjects with COPD+OSAS present marked sympathetic modulation, and the presence of OSAS in COPD subjects has a negative impact on functional capacity regardless of the severity of lung disease.

摘要

背景：本研究旨在确定慢性阻塞性肺疾病（COPD）合并阻塞性睡眠呼吸暂停综合征（OSAS）对心脏自主神经控制和功能能力的影响。 研究对象与方法：本研究为横断面前瞻性对照临床研究。通过在静息、主动体位动作（APM）、呼吸性窦性心律不齐动作（RSA-m）和6分钟步行试验（6MWT）期间采集的心电图记录，对24例COPD患者（n = 12）和COPD + OSAS患者（n = 12）的心率变异性指标进行评估和比较。 结果：与COPD + OSAS组相比，COPD组在APM期间呈现出更高的副交感神经调制（P = 0.02）。与COPD组相比，COPD + OSAS组在RSA-m期间呈现出更高的交感神经调制（P = 0.00）。尽管COPD组病情更严重，但两组在6MWT期间的表现同样受损。 结论：COPD + OSAS患者表现出明显的交感神经调制，并且COPD患者中OSAS的存在对功能能力有负面影响，而与肺部疾病的严重程度无关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c0/5927062/c5d5d37cd0ad/copd-13-1343Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c0/5927062/c5d5d37cd0ad/copd-13-1343Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c0/5927062/c5d5d37cd0ad/copd-13-1343Fig1.jpg

相似文献

[1]
Chronic obstructive pulmonary disease severity and its association with obstructive sleep apnea syndrome: impact on cardiac autonomic modulation and functional capacity.

Int J Chron Obstruct Pulmon Dis. 2018-4-26

[2]
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[3]
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[4]
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[5]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Heart Rate Variability (HRV) in Patients with Sleep Apnea and COPD: A Comprehensive Analysis.

J Clin Med. 2025-6-30

[2]
Analysis of vasoactive and oxidative stress indicators for evaluating the efficacy of continuous positive airway pressure, and relation of vasoactive and oxidative stress indicators and cardiac function in obstructive sleep Apnea Syndrome patients.

J Med Biochem. 2024-4-23

[3]
Day-night patterns in heart rate variability and complexity: differences with age and cardiopulmonary disease.

J Clin Sleep Med. 2023-5-1

[4]
Sympathetic and Vagal Nerve Activity in COPD: Pathophysiology, Presumed Determinants and Underappreciated Therapeutic Potential.

Front Physiol. 2022-6-23

[5]
Obesity as an additional factor for autonomic imbalance and poor sleep behavior in chronic obstructive pulmonary disease: a case-control study.

Clinics (Sao Paulo). 2021

[6]
Influence of Chronic Obstructive Pulmonary Disease and Moderate-To-Severe Sleep Apnoea in Overnight Cardiac Autonomic Modulation: Time, Frequency and Non-Linear Analyses.

Entropy (Basel). 2019-4-9

[7]
Impact of chronic obstructive pulmonary disease on linear and nonlinear dynamics of heart rate variability in patients with heart failure.

Braz J Med Biol Res. 2020

[8]
Comorbid obstructive sleep apnoea and chronic obstructive pulmonary disease and the risk of cardiovascular disease.

J Thorac Dis. 2018-12

本文引用的文献

[1]
Heart Rate Variability and Sleep-Related Breathing Disorders in the General Population.

Am J Cardiol. 2016-9-15

[2]
Cardiac Sympathetic Hyperactivity in Patients with Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea.

COPD. 2016-12

[3]
Correlation Analysis between Polysomnography Diagnostic Indices and Heart Rate Variability Parameters among Patients with Obstructive Sleep Apnea Hypopnea Syndrome.

PLoS One. 2016-6-2

[4]
Relationship between linear and nonlinear dynamics of heart rate and impairment of lung function in COPD patients.

Int J Chron Obstruct Pulmon Dis. 2015-8-17

[5]
Chronic obstructive pulmonary disease and heart rate variability: a literature update.

Int Arch Med. 2014-10-3

[6]
Obstructive Sleep Apnea Impairs Postexercise Sympathovagal Balance in Patients with Metabolic Syndrome.

Sleep. 2015-7-1

[7]
Heart rate recovery post 6-minute walking test in obstructive sleep apnea: cycle ergometry versus 6-minute walking test in OSA patients.

Clin Res Cardiol. 2014-5-13

[8]
Potential effect of 6 versus 12-weeks of physical training on cardiac autonomic function and exercise capacity in chronic obstructive pulmonary disease.

Eur J Phys Rehabil Med. 2015-4

[9]
Integrating the overlap of obstructive lung disease and obstructive sleep apnoea: OLDOSA syndrome.

Respirology. 2013-4

[10]
Updates on definition, consequences, and management of obstructive sleep apnea.

Mayo Clin Proc. 2011-6

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