Memar Mohammad Yousef, Ghotaslou Reza, Samiei Mohammad, Adibkia Khosro
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Microbiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Infect Drug Resist. 2018 Apr 24;11:567-576. doi: 10.2147/IDR.S142397. eCollection 2018.
Infections caused by drug-resistant pathogens are a global public health problem. The introduction of a new antimicrobial strategy is an unavoidable option for the management of drug-resistant pathogens. Induction of high levels of reactive oxygen species (ROS) by several procedures has been extensively studied for the treatment of infections. In this article, the general aspects of ROS production and the common procedures that exert their antimicrobial effects due to ROS formation are reviewed. ROS generation is the antimicrobial mechanism of nanoparticles, hyperbaric oxygen therapy, medical honey, and photodynamic therapy. In addition, it is an alternative bactericidal mechanism of clinically traditional antibiotics. The development of ROS delivery methods with a desirable selectivity for pathogens without side effects for the host tissue may be a promising approach for the treatment of infections, especially those caused by drug-resistant organisms.
由耐药病原体引起的感染是一个全球公共卫生问题。引入新的抗菌策略是管理耐药病原体的必然选择。通过多种方法诱导产生高水平的活性氧（ROS）已被广泛研究用于治疗感染。本文综述了ROS产生的一般情况以及由于ROS形成而发挥抗菌作用的常见方法。ROS生成是纳米颗粒、高压氧疗法、医用蜂蜜和光动力疗法的抗菌机制。此外，它是临床传统抗生素的一种替代杀菌机制。开发对病原体具有理想选择性且对宿主组织无副作用的ROS递送方法可能是治疗感染，尤其是由耐药生物体引起的感染的一种有前景的方法。
