Rossi Marco, Botta Cirino, Arbitrio Mariamena, Grembiale Rosa Daniela, Tagliaferri Pierosandro, Tassone Pierfrancesco
Department of Experimental and Clinical Medicine, "Magna Graecia" University of Catanzaro, Catanzaro, Italy.
Department of Health Sciences, Magna Graecia University, Catanzaro, Italy.
Oncotarget. 2018 Apr 13;9(28):20119-20133. doi: 10.18632/oncotarget.24614.
Murine models of human multiple myeloma (MM) are key tools for the study of disease biology as well as for investigation and selection of novel candidate therapeutics for clinical translation. In the last years, a variety of pre-clinical models have been generated to recapitulate a wide spectrum of biological features of MM. These systems range from spontaneous or transgenic models of murine MM, to subcutaneous or orthothopic xenografts of human MM cell lines in immune compromised animals, to platform allowing the engraftment of primary/bone marrow-dependent MM cells within a human bone marrow to fully recapitulate human disease. Selecting the right model for specific pre-clinical research is essential for the successful completion of investigation. We here review recent and most known pre-clinical murine, transgenic and humanized models of MM, focusing on major advantages and/or weaknesses in the light of different research aims.
人类多发性骨髓瘤（MM）的小鼠模型是研究疾病生物学以及研究和筛选用于临床转化的新型候选治疗药物的关键工具。在过去几年中，已经构建了多种临床前模型来概括MM的广泛生物学特征。这些系统包括小鼠MM的自发或转基因模型、免疫缺陷动物中人MM细胞系的皮下或原位异种移植，以及允许原代/骨髓依赖的MM细胞植入人骨髓以充分概括人类疾病的平台。为特定的临床前研究选择合适的模型对于成功完成研究至关重要。我们在此回顾最近和最知名的MM临床前小鼠、转基因和人源化模型，根据不同的研究目的重点关注其主要优点和/或缺点。
