Feng Yan, Liu Mafeng, Cheng Anchun
Wei Sheng Wu Xue Bao. 2016 Jul 4;56(7):1061-9.
Nearly all bacteria require iron for growth and survival. In aerobic environment, ferric iron almost cannot be utilized directly by bacteria. But ferrous iron is mainly existing in the host gastrointestinal. Soluble ferrous iron [Fe(II)] is imported directly via membrane transporters into periplasmic, then ferrous iron is imported via ferrous iron transport systems into cytoplasm. Most of gram-negative bacteria uptake ferrous iron by Feo system. The Feo transport system in Escherichia coli consists of the feoA, feoB, and feoC genes. In addition to the Feo transport system, the Yfe transport system and the Efe transport system and the Sit transport system are involved in the transport of ferrous iron. In this review, we described the component and functional mechanism of Feo system in gram-negative bacteria, to provide reference for studying other bacteria ferrous iron transport mechanism.
几乎所有细菌的生长和存活都需要铁。在有氧环境中，三价铁几乎不能被细菌直接利用。但二价铁主要存在于宿主胃肠道中。可溶性二价铁[Fe(II)]通过膜转运蛋白直接导入周质，然后通过二价铁转运系统导入细胞质。大多数革兰氏阴性菌通过Feo系统摄取二价铁。大肠杆菌中的Feo转运系统由feoA、feoB和feoC基因组成。除了Feo转运系统外，Yfe转运系统、Efe转运系统和Sit转运系统也参与二价铁的转运。在本综述中，我们描述了革兰氏阴性菌中Feo系统的组成和功能机制，为研究其他细菌的二价铁转运机制提供参考。
