Fadina V A, Razvorotnev V A
Antibiot Khimioter. 1988 Jul;33(7):527-9.
The effect of a dsRNA preparation (an interferon inductor) on DTH induced by SRBC was studied. It was shown that at optimal antigenic load the dsRNA preparation inhibited DTH whereas at suboptimal and supraoptimal loads the preparation stimulated it. The findings indicated that the dsRNA preparation had an immunoregulatory effect. The immunoregulatory properties of the preparation must be associated with its action on the lymphocyte suppressor cells and macrophages.
研究了一种双链RNA制剂(一种干扰素诱导剂)对由绵羊红细胞诱导的迟发型超敏反应(DTH)的影响。结果表明,在最佳抗原负荷下,双链RNA制剂抑制DTH,而在次最佳和超最佳负荷下,该制剂则刺激DTH。这些发现表明双链RNA制剂具有免疫调节作用。该制剂的免疫调节特性必定与其对淋巴细胞抑制细胞和巨噬细胞的作用有关。