Nosik N N, Ershov F I, Nikolaeva O V, Bukata L A, Nesterova G F
Vopr Virusol. 1984 Nov-Dec;29(6):718-20.
The paper describes derivation of double-stranded RNA from K plasmid of Sachcaromyces cerevisiae yeast by means of electrophoresis in agar gel and by differential salting out with 4 M lithium chloride. Studies in vitro and in vivo demonstrated a high interferon-inducing and antiviral activity of dsRNA preparations from the yeast plasmid.
该论文描述了通过琼脂凝胶电泳和用4M氯化锂进行分级盐析从酿酒酵母的K质粒中获得双链RNA的方法。体内外研究表明,来自酵母质粒的双链RNA制剂具有高干扰素诱导活性和抗病毒活性。