de León H, Castañeda-Hernández G, Hong E
Departamento de Farmacología y Toxicología, Instituto Politécnico Nacional de México.
Arch Inst Cardiol Mex. 1988 Jul-Aug;58(4):351-71.
The atrial natriuretic factor represents a group of atrial peptides structurally and functionally related. These peptides produce the following effects: natriuresis, diuresis, vasodilation and inhibition of aldosterone release. Its discovery in 1981 opened a new horizon in the studies on body sodium and water homeostasis, as well as on blood pressure regulation. In a few years there have been spectacular advances in the knowledge of this new hormone. However, there are still many doubts and controversies concerning its exact physiological role. Its effects on renal function, vascular contractility and its relationship with other physiological systems are not completely understood. The versatility of functions in which atrial natriuretic factor participates has pointed new trends in the research of important clinical entities such as arterial hypertension and cardiac failure, and could be a starting point for the development of novel therapeutic agents. In this work, the experimental findings dealing with the participation of atrial natriuretic factor in several biological events are reviewed.
心房利钠因子代表了一组在结构和功能上相关的心房肽。这些肽产生以下作用：利钠、利尿、血管舒张以及抑制醛固酮释放。1981年它的发现为机体钠和水平衡以及血压调节的研究开辟了新视野。在几年时间里，关于这种新激素的知识有了惊人的进展。然而，关于其确切的生理作用仍有许多疑问和争议。其对肾功能、血管收缩性的影响以及与其他生理系统的关系尚未完全明了。心房利钠因子参与的功能多样性为诸如动脉高血压和心力衰竭等重要临床病症的研究指出了新方向，并且可能成为新型治疗药物开发的起点。在这项工作中，对涉及心房利钠因子参与若干生物学事件的实验结果进行了综述。
