Pediatric Headache Clinic, Day Hospitalization Department, Schneider Children's Medical Center of Israel, Petach Tikva; affiliated; and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Cephalalgia. 2019 Jan;39(1):61-67. doi: 10.1177/0333102418776018. Epub 2018 May 6.
Allodynia is prevalent in adults with migraine and has been associated with long disease duration and severe course. Studies of the pediatric population are sparse. The aim of this study was to evaluate the rate of cephalic cutaneous allodynia in children and adolescents within the first 6 months of migraine onset and to identify associated clinical and migraine-related parameters.
The electronic database of a tertiary pediatric headache clinic from 2014 to 2017 was retrospectively searched for all children and adolescents diagnosed with migraine headache within 6 months or less of symptom onset. Cephalic cutaneous allodynia was identified by validated questionnaire. Demographics, symptoms, and headache-related parameters were compared between patients with and without allodynia.
The cohort included 119 patients, 69 girls (58.0%) and 50 (42.0%) boys, of mean age 11.6 ± 3.6 years. Mean time since onset of migraine disease was 3.6 ± 1.8 months. Cephalic cutaneous allodynia was reported by 31.1% of patients. It was significantly associated with female gender ( p = 0.03), older age at admission ( p = 0.037), older age at onset ( p = 0.042) migraine with aura ( p = 0.002), and higher rate of awakening pain ( p = 0.017).
Cephalic cutaneous allodynia may occur in children and adolescents already in the first 6 months of migraine onset. Contrary to adult studies, we found no association of allodynia with migraine frequency or long disease duration. Allodynia was significantly associated with migraine with aura, female gender, and awakening pain. A genetic tendency may contribute to the appearance of allodynia in the pediatric age group.
在偏头痛的成年人中，痛觉过敏很常见，并且与疾病持续时间长和病情严重有关。儿科人群的研究很少。本研究的目的是评估偏头痛发病后 6 个月内儿童和青少年的头部皮肤痛觉过敏发生率，并确定相关的临床和偏头痛相关参数。
回顾性检索 2014 年至 2017 年一家三级儿科头痛诊所的电子数据库，以寻找发病后 6 个月或更短时间内确诊为偏头痛头痛的所有儿童和青少年。通过经过验证的问卷确定头部皮肤痛觉过敏。比较有和无痛觉过敏患者的人口统计学、症状和头痛相关参数。
该队列包括 119 名患者，69 名女孩（58.0%）和 50 名男孩（42.0%），平均年龄为 11.6±3.6 岁。偏头痛发病后平均时间为 3.6±1.8 个月。31.1%的患者报告有头部皮肤痛觉过敏。它与女性性别（p=0.03）、入院时年龄较大（p=0.037）、发病时年龄较大（p=0.042）、有先兆偏头痛（p=0.002）和觉醒疼痛发生率较高（p=0.017）显著相关。
头部皮肤痛觉过敏可能发生在偏头痛发病后的头 6 个月内的儿童和青少年中。与成人研究不同，我们发现痛觉过敏与偏头痛频率或疾病持续时间无关。痛觉过敏与有先兆偏头痛、女性性别和觉醒疼痛显著相关。遗传倾向可能导致儿科人群出现痛觉过敏。
