Department of Clinical and Experimental Medicine, University of Catania, 95100 Catania, Italy.
Department of Biomedical and Biotechnological Sciences, University of Catania, 95100 Catania, Italy.
Curr Alzheimer Res. 2018;15(10):959-963. doi: 10.2174/1567205015666180507111958.
The progressive supranuclear palsy is a progressive neurodegenerative disease characterized by Parkinsonism, oculomotor abnormalities, early postural instability and cognitive impairment. Neurodegeneration in PSP is associated with tau protein, but the mechanisms by which tau abnormalities lead to cell dysfunction and death are not well understood. Neuro-behavioural problems related to the fear and loss of autonomy can determinate many bioethical implications. Careful planning involving patients' families, academic and industry researchers were necessary to ensure improvement in quality of life.
进行性核上性麻痹是一种进行性神经退行性疾病，其特征为帕金森病、眼球运动异常、早期姿势不稳和认知障碍。PSP 中的神经退行性变与 tau 蛋白有关，但 tau 异常如何导致细胞功能障碍和死亡的机制尚不清楚。与恐惧和失去自主性相关的神经行为问题可能会产生许多生物伦理问题。需要仔细规划，让患者的家属、学术和行业研究人员参与进来，以确保提高生活质量。
