Kułakowska Alina, Pyd Elzbieta, Halicka Dorota, Pogorzelski Robert, Drozdowski Wiesław
Klinika Neurologii Akademii Medycznej w Białymstoku.
Neurol Neurochir Pol. 2003;37 Suppl 5:203-10.
Progressive supranuclear palsy (PSP) is one of the most frequent causes of an atypical parkinsonism. The cognitive disturbances in PSP gave rise to the term "subcortical dementia". Cognitive impairment is independent of depression, which is also common in PSP. There is no correlation between cognitive impairment and either disease duration or a level of physical disability. We present a clinical picture and difficulties in PSP diagnosis in three patients--63 to 74 years old, who were hospitalized in the Department of Neurology, Medical Academy in Bialystok. A neuropsychological evaluation revealed significant differences among those patients. The patients presented with: 1. depressive and dementive syndrome, 2. executive dysfunction, 3. slowed information processing with no signs of dementia. Our findings are similar with data presented in literature and confirm the observations that: 1. there is a difference in a degree of cognitive impairment in between the patients with PSP, 2. the most frequent cognitive disturbances in PSP patients are: slowness of thought process and executive dysfunction.
进行性核上性麻痹（PSP）是非典型帕金森症最常见的病因之一。PSP中的认知障碍导致了“皮质下痴呆”这一术语的出现。认知障碍与抑郁症无关，抑郁症在PSP中也很常见。认知障碍与疾病持续时间或身体残疾程度均无关联。我们呈现了三名年龄在63至74岁之间、在比亚韦斯托克医学院神经科住院的患者的临床症状以及PSP诊断中的难点。神经心理学评估显示这些患者之间存在显著差异。这些患者表现出：1. 抑郁和痴呆综合征；2. 执行功能障碍；3. 信息处理速度减慢但无痴呆迹象。我们的研究结果与文献中的数据相似，并证实了以下观察结果：1. PSP患者之间的认知障碍程度存在差异；2. PSP患者最常见的认知障碍是：思维过程缓慢和执行功能障碍。
