Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202-5181, United States.
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202-5181, United States.
Curr Opin Immunol. 2018 Jun;52:87-92. doi: 10.1016/j.coi.2018.04.021. Epub 2018 May 4.
Many reviews on the CD1d/NKT cell axis focus on the ability of CD1d-restricted NKT cells to serve as effector cells in a variety of disorders, be they infectious diseases, cancer or autoimmunity. In contrast, here, we discuss the ways that viruses, bacteria and tumor cells can evade the CD1d/NKT cell axis. As a result, these disease states have a better chance to establish a foothold and potentially cause problems for the subsequent adaptive immune response, as the host tries to rid itself of infections or tumors.
许多关于 CD1d/NKT 细胞轴的综述都集中在 CD1d 限制性 NKT 细胞作为各种疾病（包括传染病、癌症或自身免疫性疾病）中的效应细胞的能力上。相比之下，在这里，我们讨论了病毒、细菌和肿瘤细胞逃避 CD1d/NKT 细胞轴的方式。因此，这些疾病状态有更好的机会立足，并在宿主试图清除感染或肿瘤时，可能对随后的适应性免疫反应造成问题。
