脑星形胶质细胞和小胶质细胞表达功能性 MR1 分子，将微生物抗原呈递给黏膜相关不变 T（MAIT）细胞。
Brain astrocytes and microglia express functional MR1 molecules that present microbial antigens to mucosal-associated invariant T (MAIT) cells.
机构信息
Department of Microbiology and Immunology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
出版信息
J Neuroimmunol. 2020 Dec 15;349:577428. doi: 10.1016/j.jneuroim.2020.577428. Epub 2020 Oct 15.
Abstract
It is unknown whether brain astrocytes and microglia have the capacity to present microbial antigens via the innate immune MR1/MAIT cell axis. We have detected MAIT cells in the normal mouse brain and found that both astrocytes and microglia are MR1. When we stimulated brain astrocytes and microglia with E. coli, and then co-cultured them with MAIT cells, MR1 surface expression was upregulated and MAIT cells were activated in an antigen-dependent manner. Considering the association of MAIT cells with inflammatory conditions, including those in the CNS, the MR1/MAIT cell axis could be a novel therapeutic target in neuroinflammatory disorders.
摘要
目前尚不清楚大脑星形胶质细胞和小胶质细胞是否具有通过先天免疫 MR1/MAIT 细胞轴呈递微生物抗原的能力。我们已经在正常小鼠大脑中检测到 MAIT 细胞，并且发现星形胶质细胞和小胶质细胞均表达 MR1。当我们用大肠杆菌刺激大脑星形胶质细胞和小胶质细胞，然后将它们与 MAIT 细胞共培养时，MR1 表面表达上调，MAIT 细胞以抗原依赖性方式被激活。鉴于 MAIT 细胞与包括中枢神经系统在内的炎症条件有关，MR1/MAIT 细胞轴可能成为神经炎症性疾病的新的治疗靶点。
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Nat Commun. 2020 Jul 24;11(1):3755. doi: 10.1038/s41467-020-17307-0.
2
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3
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