Qian B, Zhao H, Xu B, Lan M
Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and MolecularEngineering, East China University of Science and Technology, Shanghai, China.
AccuTarget MediPharma Co., Shanghai, China.
Cryo Letters. 2017 Jul/Aug;38(4):305-314.
Urethral warmer and cryoheater are invented and applied in cryoablation to overcome urethral cryoinjury, but these devices cannot be fixed and precisely control the released heat which excessively reduces the effective ablation area. Current warmers enlarge the operation difficulty and decrease the precision in temperature control.
A reformed catheter termed urethral heater aims to protect the urethra and simultaneously control the released heat so as to meet the aid of doctors' convenient operation in effective therapy, device fixation and precise heat controllability.
In this paper, the temperature controller combined with temperature monitor was used to control the heating behavior of the urethral heater with the initial active temperature. The controllability and thermal protection of the urethral heater was simulated and tested, which compared with that of urethral warmer.
During the trials in vitro, the lowest temperature at the urethra surface is -3.7 degree C when one cryoprobe was introduced in the cryoablation for 15 min and -15.3 degree C with two cryoprobes. Above all, the effective cryoablation area increased with the decline of initial active temperatures.
The urethral heater is able to prevent the urethra from irreversible damage and modulate the ablation area. The delay of heat is a new way to decline the recurrence rate and facilitate the desire of aconuresis during the cryoablation.
尿道加温器和低温加热器被发明并应用于冷冻消融以克服尿道冷冻损伤，但这些装置无法固定且不能精确控制释放的热量，这过度减小了有效消融面积。现有的加温器增加了操作难度并降低了温度控制的精度。
一种改良的导管，即尿道加热器，旨在保护尿道并同时控制释放的热量，以满足医生在有效治疗、装置固定和精确热可控性方面方便操作的需求。
在本文中，结合温度监测器的温度控制器用于控制具有初始激活温度的尿道加热器的加热行为。对尿道加热器的可控性和热保护进行了模拟和测试，并与尿道加温器进行了比较。
在体外试验期间，当在冷冻消融中引入一个冷冻探头15分钟时，尿道表面的最低温度为-3.7℃，引入两个冷冻探头时为-15.3℃。最重要的是，有效冷冻消融面积随着初始激活温度的降低而增加。
尿道加热器能够防止尿道受到不可逆损伤并调节消融面积。延迟加热是降低复发率并促进冷冻消融期间无尿愿望的一种新方法。
