Psychiatry and Psychology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Nutr Neurosci. 2020 Jan;23(1):55-67. doi: 10.1080/1028415X.2018.1470371. Epub 2018 May 7.
Non-invasive electrical stimulation of the brain has recently been extensively investigated to regulate food craving. However, the existing literature is controversial and there are some important questions which need to be addressed about clinical and technical factors contributing to efficacy of this method. A systematic search was performed in reliable scientific databases, and 15 eligible studies were identified. The pooled standardized mean differences for the effects of transcranial direct current stimulation (tDCS) on Visual Analogue Scale, energy intake and food craving questionnaire were -0.78 [-1.12, -0.44], -0.91 [-1.38, -0.44], -0.54 [-0.85, -0.24], respectively. Subgroup analysis showed that the most important factors associated with the impact of tDCS on food craving were the population under study, current intensity of stimulation, and number of stimulation sessions. The findings of this study support a significant impact of neuromodulation of dorsolateral prefrontal cortex (DLPFC) on energy intake and food craving using tDCS. It is recommended that multisession bilateral stimulation of the DLPFC with the current intensity of 2 mA be used to reduce food craving.
最近，人们广泛研究了非侵入性脑电刺激以调节食物渴望。然而，现有文献存在争议，对于有助于该方法疗效的临床和技术因素，仍有一些重要问题需要解决。在可靠的科学数据库中进行了系统搜索，确定了 15 项符合条件的研究。经颅直流电刺激 (tDCS) 对视觉模拟量表、能量摄入和食物渴望问卷的影响的汇总标准化均数差分别为-0.78[-1.12,-0.44]、-0.91[-1.38,-0.44]、-0.54[-0.85,-0.24]。亚组分析表明，与 tDCS 对食物渴望的影响最相关的重要因素是研究人群、刺激电流强度和刺激次数。本研究的结果支持使用 tDCS 对背外侧前额叶皮层 (DLPFC) 进行神经调节对能量摄入和食物渴望具有显著影响。建议使用 2 mA 的电流强度对 DLPFC 进行双侧多疗程刺激，以减少食物渴望。
