Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ, United States.
Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ, United States.
Behav Brain Res. 2024 Oct 2;474:115201. doi: 10.1016/j.bbr.2024.115201. Epub 2024 Aug 14.
Transcranial direct stimulation (tDCS) targeted to the dorsolateral prefrontal cortex (DLPFC) reduces food intake and hunger, but its effects on circulating factors are unclear. We assessed the effect of repeated administration of tDCS to the left DLPFC (L-DLPFC) on concentrations of pro/anti-inflammatory and appetitive hormone concentrations.
Twenty-nine healthy adults with obesity (12 M; 42±11 y; BMI=39±8 kg/m) received 3 consecutive inpatient sessions of either anodal or sham tDCS targeted to the L-DLPFC during a period of ad libitum food intake. Fasting plasma concentrations of IL-6, orexin, cortisol, TNF-α, IL-1β, ghrelin, PYY, and GLP-1 were measured before the initial and after the final tDCS sessions.
IL-6 (β=-0.92 pg/ml p=0.03) decreased in the anodal group compared with sham, even after adjusting for kcal intake; there were no changes in other hormones. Mean kcal intake was associated with higher IL-1β and ghrelin concentrations after the ad libitum period (β=0.00018 pg/ml/kcal, p=0.03; β=0.00011 pg/ml/kcal, p=0.02; respectively), but not differ by intervention groups.
IL-6 concentrations were reduced following anodal tDCS to the L-DLPFC independent of ad libitum intake. IL-6 concentrations reflect the inflammatory state of adiposity and may affect eating behavior and weight gain. These findings provide evidence of therapeutic benefit of tDCS.
经颅直流电刺激（tDCS）靶向背外侧前额叶皮层（DLPFC）可减少食物摄入和饥饿感，但对循环因子的影响尚不清楚。我们评估了重复给予左 DLPFC（L-DLPFC）tDCS 对促炎/抗炎和食欲激素浓度的影响。
29 名肥胖的健康成年人（12 名男性；42±11 岁；BMI=39±8kg/m）在自由进食期间接受 3 次连续的左 DLPFC 或假 tDCS 治疗。在初始和最后一次 tDCS 治疗前后测量空腹血浆中 IL-6、食欲素、皮质醇、TNF-α、IL-1β、ghrelin、PYY 和 GLP-1 的浓度。
与假刺激相比，阳极组的 IL-6（β=-0.92pg/ml，p=0.03）降低，即使在调整了卡路里摄入量后也是如此；其他激素没有变化。平均卡路里摄入量与自由进食后 IL-1β和 ghrelin 浓度升高有关（β=0.00018pg/ml/千卡，p=0.03；β=0.00011pg/ml/千卡，p=0.02；分别），但与干预组无关。
无论自由摄入如何，L-DLPFC 阳极 tDCS 后 IL-6 浓度均降低。IL-6 浓度反映了肥胖的炎症状态，可能影响进食行为和体重增加。这些发现为 tDCS 的治疗益处提供了证据。
