Zou Qingsong, Fu Qiang
Department of Urology, Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Asian J Urol. 2018 Apr;5(2):57-68. doi: 10.1016/j.ajur.2017.06.010. Epub 2017 Jun 23.
Several urinary tract pathologic conditions, such as strictures, cancer, and obliterations, require reconstructive plastic surgery. Reconstruction of the urinary tract is an intractable task for urologists due to insufficient autologous tissue. Limitations of autologous tissue application prompted urologists to investigate ideal substitutes. Tissue engineering is a new direction in these cases. Advances in tissue engineering over the last 2 decades may offer alternative approaches for the urinary tract reconstruction. The main components of tissue engineering include biomaterials and cells. Biomaterials can be used with or without cultured cells. This paper focuses on cell sources, biomaterials, and existing methods of tissue engineering for urinary tract reconstruction in China. The paper also details challenges and perspectives involved in urinary tract reconstruction.
几种泌尿系统病理状况,如狭窄、癌症和闭塞,需要进行整形修复手术。由于自体组织不足,泌尿系统重建对泌尿外科医生来说是一项棘手的任务。自体组织应用的局限性促使泌尿外科医生去研究理想的替代物。组织工程是这些情况下的一个新方向。过去20年组织工程的进展可能为泌尿系统重建提供替代方法。组织工程的主要组成部分包括生物材料和细胞。生物材料可以与培养细胞一起使用,也可以不使用培养细胞。本文重点介绍中国泌尿系统重建的细胞来源、生物材料和现有的组织工程方法。本文还详细阐述了泌尿系统重建所涉及的挑战和前景。