Department of Urology, The First Hospital of Jilin University, 1 Xinmin Street, Changchun, 130061, People's Republic Of China.
Department of Orthopedics, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun, 130041, People's Republic Of China.
J Nanobiotechnology. 2022 Aug 31;20(1):392. doi: 10.1186/s12951-022-01599-z.
Injuries to the urethra can be caused by malformations, trauma, inflammation, or carcinoma, and reconstruction of the injured urethra is still a significant challenge in clinical urology. Implanting grafts for urethroplasty and end-to-end anastomosis are typical clinical interventions for urethral injury. However, complications and high recurrence rates remain unsatisfactory. To address this, urethral tissue engineering provides a promising modality for urethral repair. Additionally, developing tailor-made biomimetic natural and synthetic grafts is of great significance for urethral reconstruction. In this work, tailor-made biomimetic natural and synthetic grafts are divided into scaffold-free and scaffolded grafts according to their structures, and the influence of different graft structures on urethral reconstruction is discussed. In addition, future development and potential clinical application strategies of future urethral reconstruction grafts are predicted.
尿道损伤可由畸形、创伤、炎症或癌引起，重建受损的尿道仍然是临床泌尿科的一个重大挑战。尿道成形术和端端吻合术是治疗尿道损伤的典型临床干预措施。然而，并发症和高复发率仍不理想。为了解决这个问题，尿道组织工程为尿道修复提供了一种很有前途的方法。此外，开发定制的仿生天然和合成移植物对于尿道重建具有重要意义。在这项工作中，根据结构将定制的仿生天然和合成移植物分为无支架和有支架移植物，并讨论了不同移植物结构对尿道重建的影响。此外，还预测了未来尿道重建移植物的未来发展和潜在临床应用策略。
