Hennipman A, van Oirschot B A, Smits J, Rijksen G, Staal G E
Surgical Department, University Hospital, The Netherlands.
Tumour Biol. 1988;9(5):241-8. doi: 10.1159/000217568.
The activities of hexokinase, phosphofructokinase, aldolase, enolase and pyruvate kinase were studied in breast cancer metastases occurring at various sites and compared with the enzyme activities in a series of primary breast cancers. The activities of all enzymes studied were significantly higher in the metastases compared to the primary tumors (p less than or equal to 0.05). However, no changes in the isoenzyme patterns of enolase and pyruvate kinase were observed when the metastases were compared with primary breast cancers. Differences in location of the metastases did not lead to differences in enzyme activities. Our data suggest an association of an increasing rate of glycolysis with tumor progression.
研究了己糖激酶、磷酸果糖激酶、醛缩酶、烯醇化酶和丙酮酸激酶在发生于不同部位的乳腺癌转移灶中的活性，并与一系列原发性乳腺癌中的酶活性进行了比较。与原发性肿瘤相比，所有研究酶的活性在转移灶中均显著更高（p≤0.05）。然而，当将转移灶与原发性乳腺癌进行比较时，未观察到烯醇化酶和丙酮酸激酶同工酶模式的变化。转移灶位置的差异并未导致酶活性的差异。我们的数据表明糖酵解速率增加与肿瘤进展之间存在关联。
