Wang Lingling, Zhang Shizhen, Wang Xiaochen
Department of Breast Surgery, Zhejiang Provincial People's Hospital, Hangzhou, China.
Department of Surgical Oncology and Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Oncol. 2021 Jan 7;10:602416. doi: 10.3389/fonc.2020.602416. eCollection 2020.
Breast cancer is one of the most common malignancy among women worldwide. Metastasis is mainly responsible for treatment failure and is the cause of most breast cancer deaths. The role of metabolism in the progression and metastasis of breast cancer is gradually being emphasized. However, the regulatory mechanisms that conduce to cancer metastasis by metabolic reprogramming in breast cancer have not been expounded. Breast cancer cells exhibit different metabolic phenotypes depending on their molecular subtypes and metastatic sites. Both intrinsic factors, such as amplification, , and mutations, and extrinsic factors, such as hypoxia, oxidative stress, and acidosis, contribute to different metabolic reprogramming phenotypes in metastatic breast cancers. Understanding the metabolic mechanisms underlying breast cancer metastasis will provide important clues to develop novel therapeutic approaches for treatment of metastatic breast cancer.
乳腺癌是全球女性中最常见的恶性肿瘤之一。转移是导致治疗失败的主要原因，也是大多数乳腺癌死亡的原因。代谢在乳腺癌进展和转移中的作用正逐渐受到重视。然而，乳腺癌中通过代谢重编程导致癌症转移的调控机制尚未阐明。乳腺癌细胞根据其分子亚型和转移部位表现出不同的代谢表型。内在因素，如扩增、 、和突变，以及外在因素，如缺氧、氧化应激和酸中毒，都导致转移性乳腺癌中不同的代谢重编程表型。了解乳腺癌转移背后的代谢机制将为开发治疗转移性乳腺癌的新治疗方法提供重要线索。
