School of Health and Related Research, University of Sheffield, Regent Court, 30 Regent Street, Sheffield, S1 4DA, UK.
School of Social Sciences, Leeds Beckett University, Leeds, UK.
Patient. 2018 Oct;11(5):489-502. doi: 10.1007/s40271-018-0307-7.
The aim of this study was to identify domains that determine quality of life in patients with peripheral arterial disease and find the patient-reported outcome measures that can examine the identified themes.
A systematic review of all the main six databases was undertaken to identify primary qualitative studies reporting on the health and/or quality of life of patients with peripheral arterial disease. The quality of studies was assessed using the Critical Appraisal Skills Program criteria. Findings from the included studies were analysed using framework analysis methodology. The identified themes were mapped against the items/domains of validated patient-reported outcome measures used in patients with peripheral arterial disease.
The systematic review identified eight papers that fulfilled the inclusion criteria. The included papers reported the views of 186 patients with peripheral arterial disease including patients with intermittent claudication, critical ischaemia and amputation secondary to peripheral arterial disease. The overall quality of the included studies was good based on Critical Appraisal Skills Program criteria. Framework analysis identified 35 themes that were divided into six main groups: symptoms, impact on physical functioning, impact on social functioning, psychological impact, financial impact and process of care. The best-fit generic and disease-specific patient-reported outcome measures were the Nottingham Health Profile and the Vascular Quality of Life Questionnaire, respectively. None of the patient-reported outcome measures covered all the themes important to patients with peripheral arterial disease.
The findings from the review identified the important domains that affect patients living with peripheral arterial disease. None of the current generic and disease-specific patient-reported outcome measures provide a comprehensive measure for all themes that impact the daily living of patients with peripheral arterial disease.
本研究旨在确定外周动脉疾病患者生活质量的决定因素，并找到可检验所确定主题的患者报告结局测量指标。
系统检索了所有六个主要数据库，以确定报告外周动脉疾病患者健康和/或生活质量的主要定性研究。使用关键评估技能计划标准评估研究质量。使用框架分析方法分析纳入研究的结果。将确定的主题与用于外周动脉疾病患者的经过验证的患者报告结局测量指标的项目/领域进行映射。
系统综述确定了符合纳入标准的八篇论文。纳入的论文报告了 186 名外周动脉疾病患者的观点，包括间歇性跛行、严重缺血和外周动脉疾病导致的截肢患者。根据关键评估技能计划标准，纳入研究的总体质量良好。框架分析确定了 35 个主题，分为六个主要组：症状、对身体功能的影响、对社会功能的影响、心理影响、经济影响和治疗过程。最合适的通用和疾病特异性患者报告结局测量指标分别是诺丁汉健康概况和血管生活质量问卷。目前没有任何患者报告结局测量指标涵盖对外周动脉疾病患者重要的所有主题。
综述结果确定了影响外周动脉疾病患者生活的重要领域。目前没有通用和疾病特异性患者报告结局测量指标能够全面衡量影响外周动脉疾病患者日常生活的所有主题。
