Wu Yi-Tian, He He, Wang Xia, Zhang Mei, An Zhen-Mei, Huang Heng-Jian
Department of Laboratory Medicine,West China Hospital,Sichuan University,Chengdu 610041,China.
Department of Endocrinology and Metabolism,West China Hospital,Sichuan University,Chengdu 610041,China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2018 Jan;49(1):69-73.
To determine the correlation between serum uric acid (SUA) and insulin secretion function in patients with pre-diabetes and type-2 diabetes mellitus (T2DM).
A total of 4 112 adult people participated in this study. They were divided into three groups according to the results of oral glucose tolerance test (OGTT): 493 with normal glucose regulation (NGR),1 251 with impaired glucose regulation (IGR),and 2 368 with T2DM. Their levels of SUA,fasting insulin (FIns),2 h post-meal insulin (2 h-Ins),and insulin resistance index (HOMA-IR) were determined. Correlations between SUA and insulin secretion and HOMA-IR were estimated.
IGR patients had higher levels of SUA and 2 h-Ins compared with those with NGR and T2DM ( <0.000 1). T2DM patients had higher levels of FIns,glucosylated hemoglobin (HbA1c) and HOMA-IR compared with those with NGR and IGR ( <0.000 1). In both male and female participants,the highest level of 2 h-Ins appeared in those with IGR,while T2DM had the highest level of HOMA-IA and HbA1c. FIns,2 h-Ins and HOMA-IR increased with SUA in both patients with IGR and T2DM. HbA1c decreased with SUA in T2DM patients.
High serum SUA is correlated with islet β-cell dysfunction. It may become an indicator of progression from pre-diabetes to T2DM.
确定糖尿病前期和2型糖尿病（T2DM）患者血清尿酸（SUA）与胰岛素分泌功能之间的相关性。
共有4112名成年人参与本研究。根据口服葡萄糖耐量试验（OGTT）结果将他们分为三组：493例葡萄糖调节正常（NGR）者、1251例葡萄糖调节受损（IGR）者和2368例T2DM患者。测定他们的SUA、空腹胰岛素（FIns）、餐后2小时胰岛素（2h-Ins）和胰岛素抵抗指数（HOMA-IR）水平。评估SUA与胰岛素分泌及HOMA-IR之间的相关性。
与NGR和T2DM患者相比，IGR患者的SUA和2h-Ins水平更高（<0.0001）。与NGR和IGR患者相比，T2DM患者的FIns、糖化血红蛋白（HbA1c）和HOMA-IR水平更高（<0.0001）。在男性和女性参与者中，IGR者的2h-Ins水平最高，而T2DM者的HOMA-IA和HbA1c水平最高。IGR和T2DM患者的FIns、2h-Ins和HOMA-IR均随SUA升高。T2DM患者的HbA1c随SUA降低。
高血清SUA与胰岛β细胞功能障碍相关。它可能成为糖尿病前期进展为T2DM的一个指标。
