Failure of a dengue 1 sub-unit vaccine to protect mice against a lethal dengue virus infection.
作者信息
Aaskov J G, Williams L, Fletcher J, Hay R
机构信息
Department of Medical Laboratory Science, Queensland Institute of Technology, Brisbane, Australia.
出版信息
Am J Trop Med Hyg. 1988 Nov;39(5):511-8. doi: 10.4269/ajtmh.1988.39.511.
PMID:2973756
Abstract
Mice immunized with DEN-1 pre-matrix protein produced antibody which reacted with dengue virus infected cells and intact virions but failed to neutralize virus in vitro or in vivo. Newborn mice passively immunized with anti-DEN-1 pre-matrix antibody also failed to survive intracerebral infection with 100 LD50 of any dengue virus serotype.
摘要
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