Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China.
Department of Hospital Infection Management, The Third People's Hospital of Hainan Province, Sanya, China.
J Med Virol. 2018 Sep;90(9):1444-1452. doi: 10.1002/jmv.25222. Epub 2018 May 25.
Human parechoviruses (HPeVs) are prevalent in young children; however, their effects are incompletely understood. We investigated the prevalence, genotype distribution, and phylogeny of HPeVs in individuals with diarrhea (n = 430) and healthy controls (n = 93) by the analysis of stool specimens collected from July 2013 to December 2014; 51 (11.86%) and 6 (6.45%) specimens were HPeV positive, respectively. HPeV1A occurred in 28 (6.51%) and 6 (6.45%) individuals with diarrhea and controls, respectively, whereas HPeV1B (3.95%), HPeV3 (0.23%), HPeV4 (0.70%), and HPeV14 (a rare genotype, 0.47%) were only detected in individuals with diarrhea. There was no significant difference in the rate of HPeV detection between the 2 groups; however, the mean age of HPeV infection was significantly lower in males. We conclude that HPeVs may be opportunistic pathogens associated with acute diarrhea. Immunocompromised individuals, such as children aged under 2 years and the elderly, could be vulnerable to HPeV infections.
人类肠道病毒（HPeVs）在幼儿中普遍存在，但它们的作用尚未完全了解。我们通过分析 2013 年 7 月至 2014 年 12 月采集的粪便标本，调查了腹泻患者（n=430）和健康对照者（n=93）中 HPeV 的流行率、基因型分布和系统发育；分别有 51（11.86%）和 6（6.45%）个标本 HPeV 阳性。腹泻患者和对照组中分别有 28（6.51%）和 6（6.45%）个体出现 HPeV1A，而 HPeV1B（3.95%）、HPeV3（0.23%）、HPeV4（0.70%）和 HPeV14（一种罕见基因型，0.47%）仅在腹泻患者中检出。两组 HPeV 的检出率无显著差异；但 HPeV 感染的平均年龄在男性中显著较低。我们得出结论，HPeVs 可能是与急性腹泻相关的机会性病原体。免疫功能低下的个体，如 2 岁以下儿童和老年人，可能容易受到 HPeV 感染。
