Department of Computer Graphics and Design, Human Computer Interaction Laboratory, Faculty of Informatics, Masaryk University, Brno, Czech Republic.
Loschmidt Laboratories, Department of Experimental Biology and Research Centre for Toxic Compounds in the Environment, Faculty of Science, Masaryk University, Brno, Czech Republic.
Bioinformatics. 2018 Oct 15;34(20):3586-3588. doi: 10.1093/bioinformatics/bty386.
Studying the transport paths of ligands, solvents, or ions in transmembrane proteins and proteins with buried binding sites is fundamental to the understanding of their biological function. A detailed analysis of the structural features influencing the transport paths is also important for engineering proteins for biomedical and biotechnological applications.
CAVER Analyst 2.0 is a software tool for quantitative analysis and real-time visualization of tunnels and channels in static and dynamic structures. This version provides the users with many new functions, including advanced techniques for intuitive visual inspection of the spatiotemporal behavior of tunnels and channels. Novel integrated algorithms allow an efficient analysis and data reduction in large protein structures and molecular dynamic simulations.
CAVER Analyst 2.0 is a multi-platform standalone Java-based application. Binaries and documentation are freely available at www.caver.cz.
Supplementary data are available at Bioinformatics online.
研究配体、溶剂或离子在跨膜蛋白和埋藏结合位点蛋白中的传输路径对于理解它们的生物功能至关重要。分析影响传输路径的结构特征对于为生物医学和生物技术应用工程蛋白质也很重要。
CAVER Analyst 2.0 是一个用于定量分析和实时可视化静态和动态结构中隧道和通道的软件工具。此版本为用户提供了许多新功能，包括用于直观检查隧道和通道时空行为的高级技术。新的集成算法允许在大型蛋白质结构和分子动力学模拟中进行高效的分析和数据简化。
CAVER Analyst 2.0 是一个多平台的独立基于 Java 的应用程序。二进制文件和文档可在 www.caver.cz 上免费获得。
补充数据可在生物信息学在线获得。
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