He Xiaoxia, Zhao Junwei, Fu Shihong, Yao Lisi, Gao Xiaoyan, Liu Yan, He Ying, Liang Guodong, Wang Huanyu
1 Department of Viral Encephalitis, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention , Beijing, People's Republic of China .
2 State Key Laboratory of Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention , Beijing, People's Republic of China .
Vector Borne Zoonotic Dis. 2018 Oct;18(10):554-559. doi: 10.1089/vbz.2017.2173. Epub 2018 May 9.
Tick-borne encephalitis virus (TBEV) causes neurological infections with serious sequelae in Europe and Northeast Asia. In China, the major epidemic areas are along the borders with Russia and North Korea. Although several TBEV isolates have been reported, the biological characteristics of the Chinese strains, especially those along the China-North Korea border, are unclear. In this study, we detected seven TBEV fragment sequences in 602 adult Dermacentor silvarum collected in the Changbai Mountain area of Jilin Province on the China-North Korea border and characterized the genome of three TBEV strains (JLCB11-08, JLCB11-35, and JLCB11-40). These three TBEV strains belong to the TBEV-Far Eastern (TBEV-FE) genotype and clustered most closely with the Svetlogorie and Kavalerovo strains from Russia. In addition, the TBEV strains from Northeast China clustered geographically within the TBEV-FE subtype branch. These findings will facilitate further research on the distinct genetic groupings of TBEV strains in China.
蜱传脑炎病毒（TBEV）在欧洲和东北亚地区引发具有严重后遗症的神经感染。在中国，主要流行地区位于与俄罗斯和朝鲜接壤的边境地带。尽管已有数株TBEV分离株的报道，但中国毒株，尤其是中朝边境地区毒株的生物学特性尚不清楚。在本研究中，我们在中国-朝鲜边境吉林省长白山地区采集的602只成年森林革蜱中检测到7条TBEV片段序列，并对3株TBEV毒株（JLCB11-08、JLCB11-35和JLCB11-40）的基因组进行了特征分析。这3株TBEV毒株属于TBEV-远东（TBEV-FE）基因型，与来自俄罗斯的斯韦特洛戈尔斯克株和卡瓦列罗沃株亲缘关系最近。此外，来自中国东北的TBEV毒株在地理上聚集于TBEV-FE亚型分支内。这些发现将有助于进一步研究中国TBEV毒株的不同基因分组。
