Functional Brain Mapping Laboratory, Department of fundamental neuroscience, University of Geneva, Geneva, Switzerland.
Functional Brain Mapping Laboratory, Department of fundamental neuroscience, University of Geneva, Geneva, Switzerland.
Dev Cogn Neurosci. 2018 Jun;31:58-66. doi: 10.1016/j.dcn.2018.04.011. Epub 2018 Apr 30.
While many insights on brain development and aging have been gained by studying resting-state networks with fMRI, relating these changes to cognitive functions is limited by the temporal resolution of fMRI. In order to better grasp short-lasting and dynamically changing mental activities, an increasing number of studies utilize EEG to define resting-state networks, thereby often using the concept of EEG microstates. These are brief (around 100 ms) periods of stable scalp potential fields that are influenced by cognitive states and are sensitive to neuropsychiatric diseases. Despite the rising popularity of the EEG microstate approach, information about age changes is sparse and nothing is known about sex differences. Here we investigated age and sex related changes of the temporal dynamics of EEG microstates in 179 healthy individuals (6-87 years old, 90 females, 204-channel EEG). We show strong sex-specific changes in microstate dynamics during adolescence as well as at older age. In addition, males and females differ in the duration and occurrence of specific microstates. These results are of relevance for the comparison of studies in populations of different age and sex and for the understanding of the changes in neuropsychiatric diseases.
虽然通过功能磁共振成像（fMRI）研究静息态网络已经获得了许多关于大脑发育和衰老的见解，但由于 fMRI 的时间分辨率有限，这些变化与认知功能的关联受到限制。为了更好地掌握短暂且动态变化的心理活动，越来越多的研究利用脑电图（EEG）来定义静息态网络，从而经常使用 EEG 微观状态的概念。这些微观状态是短暂的（约 100 毫秒）稳定头皮电位场的时期，受到认知状态的影响，并且对神经精神疾病敏感。尽管 EEG 微观状态方法越来越受欢迎，但有关年龄变化的信息很少，并且对性别差异一无所知。在这里，我们研究了 179 名健康个体（6-87 岁，90 名女性，204 通道 EEG）中 EEG 微观状态的时间动态的年龄和性别相关变化。我们发现在青春期以及老年时，微观状态动态存在强烈的性别特异性变化。此外，男性和女性在特定微观状态的持续时间和出现方面存在差异。这些结果对于不同年龄和性别的人群研究的比较以及对神经精神疾病变化的理解具有重要意义。
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