Ma Chengquan, Sun Erlin, Lu Bingxin
Department of Urology, Tianjin Nankai Hospital Tianjin Institute of Urology, The 2nd Hospital of Tianjin Medical University Department of Urology, Tianjin Nankai Hospital, Tianjin, China.
Medicine (Baltimore). 2018 May;97(19):e0614. doi: 10.1097/MD.0000000000010614.
Malignant pheochromocytoma is a rare disease and surgical resection is the only curative treatment.
An 81-year-old man of Chinese ethnicity was found to have a giant retroperitoneal tumor.
B-scan ultrasonography and CT scan presented a mass above the left kidney, measuring 13.5 × 10 .6 × 9.8 cm. Subsequent analysis of 24-h urinary catecholamines and vanillylmandelic acid, as well as of blood catecholamines and blood cortisol, showed no elevated levels.
The patient was treated with surgery.
The result from immunohistochemical staining confirmed the presence of malignant pheochromocytoma. After three months follow-up, the blood pressure and serum potassium were all within normal limits, no post-operative complications, no tumor recurrence and metastasis were found.
This is the oldest patient known to have histologic documentation of this disease. Giant malignant pheochromocytomas are rare entities requiring clinical suspicion coupled with strategic diagnostic evaluation to confirm the diagnosis, personalized therapeutic treatment is required, particularly among elderly population.
恶性嗜铬细胞瘤是一种罕见疾病，手术切除是唯一的治愈性治疗方法。
一名81岁的华裔男性被发现患有巨大的腹膜后肿瘤。
B超和CT扫描显示左肾上方有一个肿块，大小为13.5×10.6×9.8厘米。随后对24小时尿儿茶酚胺和香草扁桃酸以及血儿茶酚胺和血皮质醇进行分析，结果显示水平未升高。
该患者接受了手术治疗。
免疫组化染色结果证实为恶性嗜铬细胞瘤。经过三个月的随访，血压和血钾均在正常范围内，未发现术后并发症，也未发现肿瘤复发和转移。
这是已知有该疾病组织学记录的年龄最大的患者。巨大恶性嗜铬细胞瘤是罕见的病例，需要临床怀疑并结合策略性诊断评估以确诊，需要个性化的治疗，尤其是在老年人群中。
