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老年患者复发性嗜铬细胞瘤。

Recurrent Pheochromocytoma in an Elderly Patient.

机构信息

Loyola Medical Center/Edward Hines, Jr. VA Hospital, Maywood, IL 60141, USA.

出版信息

Medicina (Kaunas). 2020 Jun 26;56(6):316. doi: 10.3390/medicina56060316.

DOI:10.3390/medicina56060316
PMID:32604789
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7353891/
Abstract

Pheochromocytomas are rare neuroendocrine tumors that can affect people of all ages and are commonly diagnosed in the 4th and 5th decades of life. Familial pheochromocytomas are diagnosed mostly between the 2nd and 3rd decades of life. They can be benign or metastatic and often present as isolated tumors or along with other neuroendocrine syndromes. We present a case of an elderly man who underwent laparoscopic adrenalectomy for pheochromocytoma at the age of 60 years but developed recurrence of metastatic pheochromocytoma after ten years. We also conducted a literature review to understand the epidemiology and presentation of the tumor and to emphasize that there should be a low threshold of suspicion for timely diagnosis and management of recurrent pheochromocytoma.

摘要

嗜铬细胞瘤是一种罕见的神经内分泌肿瘤,可发生于所有年龄段人群,常见于 40 至 50 岁。家族性嗜铬细胞瘤的诊断年龄大多在 20 至 30 岁。嗜铬细胞瘤可为良性或转移性,常表现为孤立性肿瘤或伴有其他神经内分泌综合征。我们报告了 1 例 60 岁老年男性,因嗜铬细胞瘤行腹腔镜肾上腺切除术,但 10 年后发生转移性嗜铬细胞瘤复发。我们还进行了文献复习,以了解该肿瘤的流行病学和表现,并强调应保持警惕,及时诊断和治疗复发性嗜铬细胞瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0500/7353891/4202822ae800/medicina-56-00316-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0500/7353891/374db6132d47/medicina-56-00316-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0500/7353891/4202822ae800/medicina-56-00316-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0500/7353891/374db6132d47/medicina-56-00316-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0500/7353891/4202822ae800/medicina-56-00316-g002.jpg

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本文引用的文献

1
The Highs and Lows of an Unknown Pheochromocytoma in an Elderly Patient.一位老年患者未知嗜铬细胞瘤的跌宕病情
Case Rep Endocrinol. 2019 Jul 7;2019:5707968. doi: 10.1155/2019/5707968. eCollection 2019.
2
Chromogranin A in the Laboratory Diagnosis of Pheochromocytoma and Paraganglioma.嗜铬粒蛋白A在嗜铬细胞瘤和副神经节瘤实验室诊断中的应用
Cancers (Basel). 2019 Apr 25;11(4):586. doi: 10.3390/cancers11040586.
3
Giant malignant pheochromocytoma in an elderly patient: A case report.老年患者的巨大恶性嗜铬细胞瘤:一例报告
Medicine (Baltimore). 2018 May;97(19):e0614. doi: 10.1097/MD.0000000000010614.
4
Current diagnostic imaging of pheochromocytomas and implications for therapeutic strategy.嗜铬细胞瘤的当前诊断成像及其对治疗策略的影响。
Exp Ther Med. 2018 Apr;15(4):3151-3160. doi: 10.3892/etm.2018.5871. Epub 2018 Feb 14.
5
Metabologenomics of Phaeochromocytoma and Paraganglioma: An Integrated Approach for Personalised Biochemical and Genetic Testing.嗜铬细胞瘤和副神经节瘤的代谢基因组学:个性化生化和基因检测的综合方法。
Clin Biochem Rev. 2017 Apr;38(2):69-100.
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Malignant Pheochromocytoma and Paraganglioma: 272 Patients Over 55 Years.恶性嗜铬细胞瘤和副神经节瘤:272例55岁以上患者
J Clin Endocrinol Metab. 2017 Sep 1;102(9):3296-3305. doi: 10.1210/jc.2017-00992.
7
PheoSeq: A Targeted Next-Generation Sequencing Assay for Pheochromocytoma and Paraganglioma Diagnostics.PheoSeq:一种用于嗜铬细胞瘤和副神经节瘤诊断的靶向新一代测序检测方法。
J Mol Diagn. 2017 Jul;19(4):575-588. doi: 10.1016/j.jmoldx.2017.04.009. Epub 2017 May 25.
8
Update on Adrenal Tumours in 2017 World Health Organization (WHO) of Endocrine Tumours.2017 年世界卫生组织(WHO)内分泌肿瘤学肾上腺肿瘤更新。
Endocr Pathol. 2017 Sep;28(3):213-227. doi: 10.1007/s12022-017-9484-5.
9
Malignant pheochromocytoma in the elderly: which is the best management in clinical practice?老年恶性嗜铬细胞瘤:临床实践中最佳的治疗方法是什么?
Nucl Med Commun. 2015 Dec;36(12):1159-64. doi: 10.1097/MNM.0000000000000386.
10
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BMC Cancer. 2014 Jul 21;14:523. doi: 10.1186/1471-2407-14-523.