两个同源癌基因，即HST1和INT2，在人类基因组中位置紧密相邻。
Two homologous oncogenes, HST1 and INT2, are closely located in human genome.
作者信息
Wada A, Sakamoto H, Katoh O, Yoshida T, Yokota J, Little P F, Sugimura T, Terada M
机构信息
National Cancer Center Research Institute, Tokyo, Japan.
出版信息
Biochem Biophys Res Commun. 1988 Dec 15;157(2):828-35. doi: 10.1016/s0006-291x(88)80324-3.
Pulsed field gel electrophoresis and Southern blot analysis showed that the human oncogenes, HST1 and INT2, which code for proteins homologous to fibroblast growth factors, are less than 45 kb apart on the long arm of chromosome 11. Moreover, analysis of two overlapping cosmid clones, one containing INT2 and the other HST1 sequences, showed that HST1 is located about 35 kb downstream of INT2 in the same transcriptional orientation. The observed close proximity of the INT2 and HST1 genes may provide important insight on the origin and regulation of expression of these related genes.
脉冲场凝胶电泳和Southern印迹分析表明，编码与成纤维细胞生长因子同源蛋白质的人类癌基因HST1和INT2在11号染色体长臂上相距不到45 kb。此外，对两个重叠的黏粒克隆进行分析，一个包含INT2序列，另一个包含HST1序列，结果显示HST1位于INT2下游约35 kb处，转录方向相同。观察到的INT2和HST1基因的紧密相邻可能为这些相关基因的起源和表达调控提供重要线索。
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