Yoshida T, Muramatsu H, Muramatsu T, Sakamoto H, Katoh O, Sugimura T, Terada M
Genetics Division, National Cancer Center Research Institute, Tokyo, Japan.
Biochem Biophys Res Commun. 1988 Dec 15;157(2):618-25. doi: 10.1016/s0006-291x(88)80295-x.
HST1 (or HSTF1 in human gene nomenclature) transforming gene encodes a novel heparin-binding growth factor which has 40-50% homology with fibroblast growth factors and mouse Int-2 protein. Expression of mouse Hst1 or Int-2 is rare in adult tissues, but both of them are transcribed in embryos. We found that mouse Hst1 and Int-2, like their human counterparts, were located close to each other on the genome: the distance was less than 20 kbp. Hst1 was expressed in an undifferentiated mouse teratocarcinoma cell line, F9. Upon induction of differentiation of F9 cells, the amount of Hst1 transcript was markedly decreased, while that of Int-2 transcripts increased concomitantly.
HST1（在人类基因命名法中为HSTF1）转化基因编码一种新型肝素结合生长因子，它与成纤维细胞生长因子和小鼠Int-2蛋白具有40%-50%的同源性。小鼠Hst1或Int-2在成年组织中表达罕见，但两者在胚胎中均有转录。我们发现，小鼠Hst1和Int-2与其人类对应物一样，在基因组上彼此相邻：距离小于20千碱基对。Hst1在未分化的小鼠畸胎瘤细胞系F9中表达。在诱导F9细胞分化时，Hst1转录本的量显著减少，而Int-2转录本的量则随之增加。
