Department of Mechanical Engineering, College of Engineering, Kyung Hee University, Yongin, 17104, Republic of Korea.
Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University, Seoul, 05029, Republic of Korea.
Sci Rep. 2018 May 9;8(1):7312. doi: 10.1038/s41598-018-25786-x.
Men's sexual health can have significant effects on a man's self-esteem, sexual relationship and male reproductive functions. Although commercially available drugs (e.g., VIAGRA and CIALIS) show effective treatment of erectile dysfunction (ED), patients with severe ED fail to respond to these medicines. Topical nitric-oxide (NO) delivery to penis can be a painless, alternative solution with severe ED because NO triggers erection and diffuses to the trabecular arteries and smooth muscles in the penis. We here develop water-in-oil (W/O) nanoemulsions (NEs) that contain NO and can directly spread on the penis. We optimize NE formation conditions including hydrophilic-lipophilic balance (HLB) and ratio of oil, water and surfactants. Then, by spreading NEs on penis skin of intact middle aged dogs, we verify medication effects and safety of the NEs in vivo. The water-in-oil NEs can be a promising non-invasive medication for ED patients with low response to a phosphodiesterase type 5 (PDE5) inhibitor, thus increasing quality of life in the aging society.
男性的性健康会对其自尊心、性关系和男性生殖功能产生重大影响。尽管市售药物（如伟哥和希爱力）对勃起功能障碍（ED）有有效治疗作用，但严重 ED 患者对这些药物没有反应。将局部一氧化氮（NO）输送到阴茎是一种无痛苦的替代解决方案，适用于严重 ED 患者，因为 NO 会引发勃起，并扩散到阴茎的小梁动脉和平滑肌中。我们在此开发含有 NO 的油包水（W/O）纳米乳剂（NE），可以直接涂抹在阴茎上。我们优化了 NE 的形成条件，包括亲水亲油平衡（HLB）和油、水和表面活性剂的比例。然后，通过将 NE 涂抹在中年犬完整的阴茎皮肤上，我们在体内验证了 NE 的药物效果和安全性。水包油 NE 可能是一种有前途的非侵入性药物，适用于对磷酸二酯酶 5（PDE5）抑制剂反应低的 ED 患者，从而提高老龄化社会的生活质量。
